Department of Community Medicine and Behavioral Sciences, Faculty of Medicine, Kuwait University, Safat, Kuwait.
Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, Michigan, USA.
Pediatr Allergy Immunol. 2023 Jun;34(6):e13979. doi: 10.1111/pai.13979.
Fucoxanthin, a marine xanthophyll carotenoid, has been shown to exert beneficial health effects. Cell-based and animal-based experimental studies have shown that fucoxanthin has the potential to mitigate eczema symptoms. Hence, we sought to assess whether fucoxanthinol 3-arachidate, a fucoxanthin metabolite, measured in maternal serum at birth is associated with eczema development during early childhood.
Data from the 1989/1990 Isle of Wight birth cohort were analyzed. We focused on data obtained from the 1, 2, and 4 years follow-ups. Fucoxanthinol 3-arachidate was measured in maternal serum at the child's birth as abundance relative to the reference lipids. Eczema was ascertained according to parent-reported clinical history and characteristic morphology and distribution. Log-binomial regression models were used to estimate adjusted risk ratios (aRR) and their 95% confidence intervals (CI).
A total of 592 subjects (49.2% males and 50.8% females) were included in the current analysis. Associations between fucoxanthinol 3-arachidate levels and eczema risk during the first 4 years of life (longitudinal analysis) were evaluated using four modeling approaches, which showed higher fucoxanthinol 3-arachidate levels were associated with reduced eczema risk: (i) aRR = 0.88, 95% CI: 0.76-1.03; (ii) aRR = 0.67, 0.45-0.99; (iii) aRR = 0.66, 0.44-0.98; and (iv) aRR = 0.65, 0.42-0.99.
Our findings suggest that increased fucoxanthinol 3-arachidate levels measured in maternal serum at the child's birth is associated with reduced eczema risk during the first 4 years of the offspring life.
褐藻黄素是一种海洋类胡萝卜素，已被证明具有有益的健康作用。基于细胞和动物的实验研究表明，褐藻黄素具有减轻湿疹症状的潜力。因此，我们试图评估在婴儿出生时母体血清中测量的褐藻黄质 3-花生酸，一种褐藻黄素代谢物，是否与儿童早期湿疹的发展有关。
分析了 1989/1990 年怀特岛出生队列的数据。我们重点关注了从 1 岁、2 岁和 4 岁随访中获得的数据。在孩子出生时，通过与参考脂质的相对丰度来测量母体血清中的褐藻黄质 3-花生酸。湿疹是根据父母报告的临床病史以及特征性形态和分布来确定的。使用对数二项式回归模型来估计调整后的风险比 (aRR)及其 95%置信区间 (CI)。
共有 592 名受试者（49.2%为男性，50.8%为女性）纳入本研究。使用四种建模方法评估了褐藻黄质 3-花生酸水平与婴儿生命前 4 年（纵向分析）的湿疹风险之间的关联，结果显示较高的褐藻黄质 3-花生酸水平与降低湿疹风险相关：（i）aRR = 0.88，95%CI：0.76-1.03；（ii）aRR = 0.67，0.45-0.99；（iii）aRR = 0.66，0.44-0.98；（iv）aRR = 0.65，0.42-0.99。
我们的研究结果表明，在婴儿出生时母体血清中测量的褐藻黄质 3-花生酸水平升高与婴儿生命前 4 年湿疹风险降低有关。
