微小RNA在蛛网膜下腔出血诊断与治疗中的作用
MicroRNAs' Role in Diagnosis and Treatment of Subarachnoid Hemorrhage.
作者信息
Segherlou Zahra Hasanpour, Saldarriaga Lennon, Azizi Esaan, Vo Kim-Anh, Reddy Ramya, Siyanaki Mohammad Reza Hosseini, Lucke-Wold Brandon
机构信息
Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL 32661, USA.
College of Medicine, University of Florida, Gainesville, FL 32661, USA.
出版信息
Diseases. 2023 May 23;11(2):77. doi: 10.3390/diseases11020077.
Abstract
Subarachnoid hemorrhage (SAH) is most commonly seen in patients over 55 years of age and often results in a loss of many productive years. SAH has a high mortality rate, and survivors often suffer from early and secondary brain injuries. Understanding the pathophysiology of the SAH is crucial in identifying potential therapeutic agents. One promising target for the diagnosis and prognosis of SAH is circulating microRNAs, which regulate gene expression and are involved in various physiological and pathological processes. In this review, we discuss the potential of microRNAs as a target for diagnosis, treatment, and prognosis in SAH.
摘要
蛛网膜下腔出血（SAH）最常见于55岁以上的患者，常导致多年的生产能力丧失。SAH死亡率高，幸存者常遭受早期和继发性脑损伤。了解SAH的病理生理学对于确定潜在的治疗药物至关重要。SAH诊断和预后的一个有前景的靶点是循环微RNA，其调节基因表达并参与各种生理和病理过程。在本综述中，我们讨论了微RNA作为SAH诊断、治疗和预后靶点的潜力。
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