Faculty of Medicine, University of Leeds School of Medicine, Leeds LS2 9JT, UK.
Division of Dermatology, University of Ottawa, Ottawa, ON K1H 8M2, Canada.
Curr Oncol. 2023 Jun 9;30(6):5631-5651. doi: 10.3390/curroncol30060424.
Sarcomas are a heterogeneous group of mesenchymal malignancies with various genetic and environmental risk factors. This study analyzed the epidemiology of sarcomas to gain insight into the incidence and mortality rates of these cancers in Canada, as well as to elucidate their potential environmental risk factors. Data for this study were obtained from le Registre Québécois du Cancer (LRQC) and from the Canadian Cancer Registry (CCR) for the period from 1992 to 2010. Mortality data were obtained from the Canadian Vital Statistics (CVS) database for the period from 1992 to 2010 using the International Classification of Diseases for Oncology, ICD-O-3, ICD-9, or ICD-10 codes, for all subtypes of sarcomas. We found that the overall sarcoma incidence in Canada decreased during the study period. However, there were select subtypes with increasing incidence. Peripherally located sarcomas were found to have lower mortality rates compared to axially located sarcomas, as expected. Clustering of Kaposi sarcoma cases in self-identified LGBTQ+ communities and in postal codes with a higher proportion of African-Canadian and Hispanic populations was observed. Forward Sortation Area (FSA) postal codes with a lower socioeconomic status also had higher Kaposi sarcoma incidence rates.
肉瘤是一组具有不同遗传和环境风险因素的间充质恶性肿瘤。本研究分析了肉瘤的流行病学，以深入了解加拿大这些癌症的发病率和死亡率，并阐明其潜在的环境风险因素。本研究的数据来自魁北克癌症登记处（LRQC）和加拿大癌症登记处（CCR），时间范围为 1992 年至 2010 年。死亡率数据来自加拿大生命统计数据库（CVS），时间范围为 1992 年至 2010 年，使用国际肿瘤学疾病分类（ICD-O-3、ICD-9 或 ICD-10）代码，针对所有肉瘤亚型。我们发现，加拿大的总体肉瘤发病率在研究期间有所下降。然而，某些亚型的发病率却在上升。外周性肉瘤的死亡率预计比轴向性肉瘤低。卡波西肉瘤病例在自我认同的 LGBTQ+社区和非裔加拿大人和西班牙裔人口比例较高的邮政编码中存在聚集现象。社会经济地位较低的前向排序区（FSA）邮政编码的卡波西肉瘤发病率也较高。
