Zhu Mingxia, Zhang Lan, Wei Yong, Wang Xiaping, Qin Songbing, Wang Tongshan, Xu Xiaoting, Zhou Xin
Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Department of Radiation Oncology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200336, China.
BMC Cancer. 2025 Apr 17;25(1):725. doi: 10.1186/s12885-025-14136-6.
Soft tissue sarcomas (STS) are a rare group of malignant tumors originating from soft tissues. The study systematically evaluates the global burden of soft tissue and extraosseous sarcomas from 1990 to 2021 across diverse populations.
We examined incidence, mortality, and disability-adjusted life years (DALYs) using data from the Global Burden of Disease (GBD) 2021 database. Estimated annual percentage change (EAPC) assessed trends from 1990 to 2021. Cross-country inequality was evaluated using the socio-demographic index (SDI), inequality slope index, and concentration index. Decomposition analysis identified key drivers of changes in disease burden. Frontier analysis pinpointed countries with potential for improvement, while Bayesian age-period-cohort (BAPC) projected trends through 2036.
Although the absolute numbers of cases, deaths, and DALYs increased, the global age-standardized incidence rate (ASIR), mortality (ASMR), and DALYs (ASDR) decreased. Males consistently exhibited higher rates than females, with the highest rates in individuals aged 95 and older. In high-SDI regions, ASIR slightly increased, whereas ASMR and ASDR decreased. The gap between high- and low-SDI countries widened over time. Projections indicate that by 2036, absolute numbers will increase, while age-standardized rates will further decline.
Despite the increasing absolute burden, the global age-standardized rates have declined, likely reflecting multiple contributing factors. However, the persistent disparities underscore the need for improved access to care and targeted public health interventions to mitigate the global burden.
软组织肉瘤（STS）是一组起源于软组织的罕见恶性肿瘤。本研究系统评估了1990年至2021年期间不同人群中软组织和骨外肉瘤的全球负担。
我们使用全球疾病负担（GBD）2021数据库中的数据，研究发病率、死亡率和伤残调整生命年（DALY）。估计年度百分比变化（EAPC）评估了1990年至2021年的趋势。使用社会人口指数（SDI）、不平等斜率指数和集中指数评估国家间不平等情况。分解分析确定了疾病负担变化的关键驱动因素。前沿分析确定了具有改善潜力的国家，而贝叶斯年龄-时期-队列（BAPC）预测了到2036年的趋势。
尽管病例数、死亡数和DALY的绝对数量有所增加，但全球年龄标准化发病率（ASIR）、死亡率（ASMR）和DALY（ASDR）有所下降。男性的发病率始终高于女性，95岁及以上人群的发病率最高。在高SDI地区，ASIR略有上升，而ASMR和ASDR下降。随着时间的推移，高SDI国家和低SDI国家之间的差距不断扩大。预测表明，到2036年，绝对数量将增加，而年龄标准化率将进一步下降。
尽管绝对负担在增加，但全球年龄标准化率有所下降，这可能反映了多种因素。然而，持续存在的差异凸显了改善医疗服务可及性和针对性公共卫生干预措施以减轻全球负担的必要性。
