Promising Centre for Sensors and Electronic Devices (PCSED), Advanced Materials and Nano-Research Centre, Najran University, Najran 11001, Saudi Arabia.
Department of Chemistry, Faculty of Science and Arts, Najran University, Najran 11001, Saudi Arabia.
Biosensors (Basel). 2023 May 29;13(6):588. doi: 10.3390/bios13060588.
The ultimate objective of this research work is to design a sensitive and selective electrochemical sensor for the efficient detection of ascorbic acid (AA), a vital antioxidant found in blood serum that may serve as a biomarker for oxidative stress. To achieve this, we utilized a novel YbO.CuO@rGO nanocomposite (NC) as the active material to modify the glassy carbon working electrode (GCE). The structural properties and morphological characteristics of the YbO.CuO@rGO NC were investigated using various techniques to ensure their suitability for the sensor. The resulting sensor electrode was able to detect a broad range of AA concentrations (0.5-1571 µM) in neutral phosphate buffer solution, with a high sensitivity of 0.4341 µAµMcm and a reasonable detection limit of 0.062 µM. The sensor's great sensitivity and selectivity allowed it to accurately determine the levels of AA in human blood serum and commercial vitamin C tablets. It demonstrated high levels of reproducibility, repeatability, and stability, making it a reliable and robust sensor for the measurement of AA at low overpotential. Overall, the YbO.CuO@rGO/GCE sensor showed great potential in detecting AA from real samples.
本研究工作的最终目标是设计一种灵敏且选择性的电化学传感器，用于高效检测血清中重要的抗氧化剂抗坏血酸（AA），AA 可以作为氧化应激的生物标志物。为实现这一目标，我们利用新型 YbO.CuO@rGO 纳米复合材料（NC）作为活性材料来修饰玻碳工作电极（GCE）。使用各种技术研究了 YbO.CuO@rGO NC 的结构特性和形态特征，以确保其适合用作传感器。所得传感器电极能够在中性磷酸盐缓冲溶液中检测到广泛的 AA 浓度（0.5-1571µM），具有 0.4341µAµMcm 的高灵敏度和 0.062µM 的合理检测限。传感器具有很高的灵敏度和选择性，能够准确测定人血清和商业维生素 C 片中 AA 的水平。它表现出很高的重现性、重复性和稳定性，使其成为在低过电势下测量 AA 的可靠且稳健的传感器。总体而言，YbO.CuO@rGO/GCE 传感器在检测实际样品中的 AA 方面显示出很大的潜力。
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