González-Díaz Esteban, Rodríguez-Lugo Christian E, Quintero-Luce Sergio, Esparza-Ahumada Sergio, Pérez-Gómez Héctor Raúl, Morfín-Otero Rayo, Kasten-Monges Marina de Jesus, Aguirre-Díaz Sara A, Vázquez-León Marisela, Rodríguez-Noriega Eduardo
Epidemiology Unit, Hospital Civil de Guadalajara "Fray Antonio Alcalde", Guadalajara 44280, Mexico.
Instituto de Patología Infecciosa y Experimental "Dr. Francisco Ruiz Sánchez", Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44280, Mexico.
Infect Dis Rep. 2023 Jun 12;15(3):319-326. doi: 10.3390/idr15030032.
Monkeypox (Mpox) is a zoonotic viral infection endemic to Africa, which has caused a global outbreak since April 2022. The global Mpox outbreak is related to Clade IIb. The disease has primarily affected men who have sex with men. Skin lesions are concentrated in the genital area, with lymphadenopathy as well as concurrent sexually transmitted infections (STIs). This is an observational study of adult patients with a recent development of skin lesions and systemic symptoms, which could not be explained by other diseases present. Fifty-nine PCR-positive patients with prominent skin lesions in the genital area (77.9%), inguinal lymphadenopathy (49.1%), and fever (83.0%) were included. Twenty-five (42.3%) were known to be living with human immunodeficiency virus (HIV), and 14 of the HIV-naïve subjects (51.9%) were found to be positive during workup, totaling 39 (66.1%) patients with HIV. Eighteen patients (30.5%) had concurrent syphilis infections. It is worrisome that Mpox is present in large metropolitan areas of Mexico, but the underlying growth of cases of HIV infection and other STIs has not been well studied and should be evaluated in all at-risk adults and their contacts.
猴痘是一种在非洲流行的人畜共患病毒感染疾病，自2022年4月以来已引发全球疫情。全球猴痘疫情与进化枝IIb有关。该疾病主要影响男男性行为者。皮肤病变集中在生殖器部位，伴有淋巴结病以及同时存在的性传播感染（STIs）。这是一项针对近期出现皮肤病变和全身症状且无法用其他现存疾病解释的成年患者的观察性研究。纳入了59例PCR检测呈阳性的患者，这些患者生殖器部位有明显皮肤病变（77.9%）、腹股沟淋巴结病（49.1%）以及发热（83.0%）。已知25例（42.3%）患者感染了人类免疫缺陷病毒（HIV），在检查过程中发现14例未感染HIV的受试者呈阳性（51.9%），总计39例（66.1%）患者感染HIV。18例患者（30.5%）同时感染梅毒。令人担忧的是，猴痘在墨西哥的大城市地区存在，但HIV感染病例和其他性传播感染的潜在增长情况尚未得到充分研究，应对所有高危成年人及其接触者进行评估。
