Zitko M, Andrysek O, Cernovská I, Vasícková M
Neoplasma. 1986;33(3):387-91.
In two groups of patients with checked diagnoses of the malignant melanoma and Hodgkin's disease we followed changes of the renal excretion of two major pterines, neopterine and biopterine. In patients with the malignant melanoma, we found a remarkable increase of the excretion of neopterine, which depends on the extent of the involvement and, by contrast to this, in patients with Hodgkin's disease we found a remarkable decrease of the excretion of biopterine, also dependent on the extent of the involvement. In both types of the tumor disease the ratio neopterine: biopterine is remarkably increased as compared to controls.
在两组经确诊患有恶性黑色素瘤和霍奇金病的患者中，我们追踪了两种主要蝶呤（新蝶呤和生物蝶呤）的肾脏排泄变化。在恶性黑色素瘤患者中，我们发现新蝶呤排泄量显著增加，这取决于受累程度；与此形成对比的是，在霍奇金病患者中，我们发现生物蝶呤排泄量显著减少，同样取决于受累程度。在这两种肿瘤疾病中，与对照组相比，新蝶呤与生物蝶呤的比率均显著升高。
