Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department for Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
Clin Transl Gastroenterol. 2023 Sep 1;14(9):e00610. doi: 10.14309/ctg.0000000000000610.
Helicobacter pylori colonizes the human stomach. Infection causes chronic gastritis and increases the risk of gastroduodenal ulcer and gastric cancer. Its chronic colonization in the stomach triggers aberrant epithelial and inflammatory signals that are also associated with systemic alterations.
Using a PheWAS analysis in more than 8,000 participants in the community-based UK Biobank, we explored the association of H. pylori positivity with gastric and extragastric disease and mortality in a European country.
Along with well-established gastric diseases, we dominantly found overrepresented cardiovascular, respiratory, and metabolic disorders. Using multivariate analysis, the overall mortality of H. pylori -positive participants was not altered, while the respiratory and Coronovirus 2019-associated mortality increased. Lipidomic analysis for H. pylori -positive participants revealed a dyslipidemic profile with reduced high-density lipoprotein cholesterol and omega-3 fatty acids, which may represent a causative link between infection, systemic inflammation, and disease.
Our study of H. pylori positivity demonstrates that it plays an organ- and disease entity-specific role in the development of human disease and highlights the importance of further research into the systemic effects of H. pylori infection.
幽门螺杆菌定植于人类胃部。感染会导致慢性胃炎，并增加胃十二指肠溃疡和胃癌的风险。其在胃部的慢性定植会引发异常的上皮和炎症信号，这些信号也与全身改变有关。
我们在英国生物银行（UK Biobank）中超过 8000 名社区参与者中进行了 PheWAS 分析，探索了在一个欧洲国家中，幽门螺杆菌阳性与胃内和胃外疾病以及死亡率之间的关联。
除了已确立的胃部疾病外，我们还发现心血管、呼吸和代谢疾病明显增多。通过多变量分析，幽门螺杆菌阳性参与者的总体死亡率没有改变，而呼吸和 2019 年冠状病毒相关死亡率增加。对幽门螺杆菌阳性参与者的脂质组学分析显示出血脂异常的特征，高密度脂蛋白胆固醇和 omega-3 脂肪酸减少，这可能代表了感染、全身炎症和疾病之间的因果关系。
我们对幽门螺杆菌阳性的研究表明，它在人类疾病的发展中具有器官和疾病实体特异性的作用，并强调了进一步研究幽门螺杆菌感染的全身效应的重要性。
