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多幼犬归巢:新生大鼠嗅觉辨别能力的快速测试。

Multipup homing: a rapid test for olfactory discrimination in neonatal rats.

作者信息

West G L, Sobotka T J, Brodie R E, Mills-Smith M C, Quander D Y

出版信息

Neurobehav Toxicol Teratol. 1986 May-Jun;8(3):293-6.

PMID:3736759
Abstract

The multipup homing procedure (MHP) is a rapid test for olfactory discrimination performance that can be run on an entire 8-pup litter of neonatal rats in 8 min. Performance improved developmentally with age, and females tended to perform better than males. The MHP was examined for its usefulness in detecting early postnatal effects of low-level prenatal exposure to chlorpromazine (CPZ) or d-amphetamine (AMPH). CPZ increased response latencies in both males and females, but AMPH had no significant effects. The MHP appears promising for use in behavioral teratological assessment of neurobehavioral function.

摘要

多幼崽归巢程序(MHP)是一种用于嗅觉辨别能力的快速测试,可在8分钟内对一窝8只新生大鼠进行测试。随着年龄增长,表现会有所改善,且雌性往往比雄性表现更好。研究了MHP在检测产前低剂量接触氯丙嗪(CPZ)或右旋苯丙胺(AMPH)对产后早期影响方面的效用。CPZ增加了雄性和雌性的反应潜伏期,但AMPH没有显著影响。MHP在神经行为功能的行为致畸学评估中似乎很有前景。

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