Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
Transl Vis Sci Technol. 2023 Jun 1;12(6):25. doi: 10.1167/tvst.12.6.25. Epub 2023 Jun 27.
Current ocular surface diagnostic methods may not totally meet and implement the clinical demands for early and precise treatments. The tear ferning (TF) test has been known as a quick, simple, and inexpensive procedure. This study aimed to validate the TF test as an alternative method for early determination of photokeratitis status.
The tear sample was collected from the UVB-induced photokeratitis eyes and processed for TF formation. The TF patterns were graded by both the Masmali and a Sophie-Kevin (SK) grading criteria, a new set of criteria modified from the Masmali grading, for differential diagnoses. In addition, the TF test results were correlated with three clinical ocular surface indicators, including tear volume (TV), tear film break-up time (TBUT), and cornea staining, to evaluate the diagnostic capacity.
Differential diagnosis between the normal and the photokeratitis status was achieved by the TF test. The SK grading reflected earlier photokeratitis status than the Masmali grading criteria. The TF results were strongly correlated with the three clinical ocular surface indicators, particularly for the TBUT and cornea staining.
The TF test was proven to have a capacity to distinguish photokeratitis from the normal status at an early stage by using the SK grading criteria. It is therefore potentially useful for photokeratitis diagnosis in the clinical settings.
The TF test may fulfill the demands of precise and early diagnosis to facilitate in time the intervention for photokeratitis.
目前的眼表面诊断方法可能无法完全满足和实现早期和精确治疗的临床需求。泪液拉丝（TF）试验已被认为是一种快速、简单和廉价的程序。本研究旨在验证 TF 试验作为早期确定光性角膜炎状态的替代方法。
从 UVB 诱导的光性角膜炎眼中采集泪液样本并进行 TF 形成处理。TF 模式通过 Masmali 和 Sophie-Kevin（SK）分级标准进行分级，这是从 Masmali 分级标准修改而来的一套新的分级标准，用于鉴别诊断。此外，将 TF 试验结果与三个临床眼表面指标（泪液体积（TV）、泪膜破裂时间（TBUT）和角膜染色）相关联，以评估诊断能力。
TF 试验可区分正常和光性角膜炎状态。SK 分级比 Masmali 分级标准更早反映光性角膜炎状态。TF 结果与三个临床眼表面指标高度相关，尤其是 TBUT 和角膜染色。
使用 SK 分级标准，TF 试验已被证明具有在早期区分光性角膜炎和正常状态的能力。因此，它在临床环境中对光性角膜炎的诊断具有潜在的用途。
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