Dóczi T, Joó F, Adám G, Bozóky B, Szerdahelyi P
Neurosurgery. 1986 Jun;18(6):733-9. doi: 10.1227/00006123-198606000-00010.
Models have been devised and characterized in the laboratory rat for studying the neuropathology of subarachnoid hemorrhage. Several ways of injecting blood via different routes have been tried; cortical subarachnoid administration is the most reproducible suitable model. The location of injected blood was detected in histological sections. In this rat model for subarachnoid hemorrhage, the arterial blood pressure and the intracranial pressure did not elevate significantly, and the influence of major ischemic components in the development of brain edema could also be ruled out. Measurements performed on the water, electrolyte, and albumin contents of brain tissue have clearly indicated that the brain edema developing in the acute stage of rat experimental subarachnoid hemorrhage could be classified as having a primarily vasogenic component as well. These findings may have implications in the treatment of subarachnoid hemorrhage.
已经设计出了用于研究蛛网膜下腔出血神经病理学的大鼠模型并对其进行了表征。人们尝试了几种通过不同途径注入血液的方法；皮质蛛网膜下腔给药是最可重复的合适模型。在组织学切片中检测到注入血液的位置。在这个蛛网膜下腔出血的大鼠模型中，动脉血压和颅内压没有显著升高，并且也可以排除主要缺血成分在脑水肿发展中的影响。对脑组织的水、电解质和白蛋白含量进行的测量清楚地表明，大鼠实验性蛛网膜下腔出血急性期出现的脑水肿也可归类为主要具有血管源性成分。这些发现可能对蛛网膜下腔出血的治疗有启示意义。
