Parimbetova R B, Babichev V N
Neurosci Behav Physiol. 1986 Jan-Feb;16(1):12-6. doi: 10.1007/BF01186883.
Sensitivity to serotonin was investigated in single neurons of the arcuate region of the hypothalamus as the center of tonic regulation of gonadotropic function in conditions of its microiontophoretic application in different stages of the estrous cycle in rats. It was shown that at the diestrus-II stage of the estrous cycle, especially during morning hours, cells predominate among neurons of the arcuate region with activated reaction to serotonin. During proestrus increased representation of cells with inhibited reaction is noted among spontaneously functioning neurons, which is especially pronounced during evening hours of this stage of the cycle. Serotonin induced reduction in the level of luteinizing hormone in blood and this effect was usually combined with an activating effect of indolamine on functioning of neurons. The combination of a delayed effect of the neurotransmitter on spontaneous activity of neurons of the arcuate nucleus with a reduced level of luteinizing hormone in blood was noted in the overwhelming majority of cases only at the proestrus stage.
在下丘脑弓状区域的单个神经元中，研究了血清素敏感性，该区域作为促性腺功能紧张调节的中心，在大鼠发情周期不同阶段进行微离子电泳应用的条件下。结果表明，在发情周期的间情期-II阶段，尤其是在早晨时段，弓状区域神经元中对血清素呈激活反应的细胞占主导。在发情前期，自发活动的神经元中对血清素呈抑制反应的细胞比例增加，在该周期阶段的傍晚时段尤为明显。血清素可导致血液中促黄体生成素水平降低，且这种效应通常与吲哚胺对神经元功能的激活作用相结合。在绝大多数情况下，仅在发情前期阶段观察到神经递质对弓状核神经元自发活动的延迟效应与血液中促黄体生成素水平降低同时出现。
