Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Natl Toxicol Program Tech Rep Ser. 2023 Jun(602). doi: 10.22427/NTP-TR-602.
Tris(chloropropyl) phosphate (TCPP) is used as a flame retardant in textiles, furniture foam, and other related products. In addition, it is manufactured for use in construction materials, electronic products, paints, coatings, and adhesives. Several flame retardants, including structurally similar organohalogen compounds, have been removed from products in commerce due to toxicity concerns, and TCPP has been proposed as a replacement flame retardant for use in these products. An anticipated increase in use of TCPP has generated concerns for increased human exposure through oral, dermal, and inhalation routes; however, publicly available toxicity data are scarce. The U.S. Consumer Product Safety Commission therefore requested that the National Toxicology Program (NTP) form a research program on TCPP to conduct subchronic and chronic exposure studies in rats and mice for hazard identification and characterization information. Because TCPP is commercially available as an isomeric mixture, the NTP studies tested a commercial TCPP product containing four isomers commonly found in other commercial mixtures of TCPP: tris(1-chloro-2-propyl) phosphate (TCIPP; CASRN 13674-84-5), bis(2-chloro-1-methylethyl) 2-chloropropyl phosphate (CASRN 76025-08-6), bis(2-chloropropyl) 2-chloroisopropyl phosphate (CASRN 76649-15-5), and tris(2-chloropropyl) phosphate (CASRN 6145-73-9). Following procurement of TCPP, the percent purity of the four isomers was determined prior to conducting hazard characterization studies. (Abstract Abridged).
磷酸三（氯丙基）酯（TCPP）用作纺织品、家具泡沫和其他相关产品中的阻燃剂。此外，它还用于建筑材料、电子产品、油漆、涂料和粘合剂的制造。由于毒性问题，一些阻燃剂，包括结构相似的有机卤化合物，已从商业产品中去除，TCPP 已被提议作为这些产品的替代阻燃剂。预计 TCPP 的使用增加会引起人们对通过口服、皮肤和吸入途径增加接触的担忧；然而，可公开获得的毒性数据很少。因此，美国消费品安全委员会要求国家毒理学计划（NTP）制定关于 TCPP 的研究计划，以便在大鼠和小鼠中进行亚慢性和慢性暴露研究，以确定危害识别和特征信息。由于 TCPP 可作为异构体混合物商业上可获得，因此 NTP 研究测试了一种商业 TCPP 产品，其中包含四种在其他 TCPP 商业混合物中常见的异构体：磷酸三（1-氯-2-丙基）酯（TCIPP；CASRN 13674-84-5）、二（2-氯-1-甲基乙基）2-氯丙基磷酸酯（CASRN 76025-08-6）、二（2-氯丙基）2-氯异丙基磷酸酯（CASRN 76649-15-5）和磷酸三（2-氯丙基）酯（CASRN 6145-73-9）。在采购 TCPP 后，在进行危害特征描述研究之前，确定了四种异构体的纯度百分比。（摘要缩写）。
