恶性脑肿瘤化疗的未来。
The future of chemotherapy in malignant brain tumors.
作者信息
Calliauw L, Sieben G
出版信息
Neurosurg Rev. 1986;9(1-2):27-30. doi: 10.1007/BF01743050.
PMID:3736902
Abstract
Malignant brain tumors respond poorly to chemotherapy. This therapeutic resistance is the result of the marked heterogeneity of malignant gliomas in vivo and in vitro. Different factors, as specific markers, DNA distribution curves, morphology, chromosomal constitution, invasiveness and growth characteristics are considered for the understanding of the biology of malignant brain tumors. A better knowledge of this biology should provide new chemotherapeutic strategies.
摘要
恶性脑肿瘤对化疗反应不佳。这种治疗抗性是恶性胶质瘤在体内和体外显著异质性的结果。为了理解恶性脑肿瘤的生物学特性，人们考虑了不同的因素，如特定标志物、DNA分布曲线、形态、染色体组成、侵袭性和生长特征。对这种生物学特性的更深入了解应该能提供新的化疗策略。
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