Polanowski Paweł, Nasiek Aleksandra, Grządziel Aleksandra, Chmielik Ewa, Pietruszka Agnieszka, Składowski Krzysztof, Polanowska Katarzyna
1st Radiation and Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-102 Gliwice, Poland.
3rd Radiation and Clinical Oncology Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, 44-102 Gliwice, Poland.
Biomedicines. 2023 May 26;11(6):1538. doi: 10.3390/biomedicines11061538.
Sebaceous carcinoma is a rare malignancy that should be treated with surgical resection. Nonetheless, a dynamic and aggressive course of the disease may disqualify a patient from this treatment. Applying radiotherapy with the escalation dose using a stereotactic boost is worthy of consideration as a radical treatment. In this paper, we present the case study of a young patient with a tumor localized in the periocular area. The patient was treated with operation two times without a satisfactory effect. Conventional radiotherapy, 60 Gy in 30 fractions, combined with chemotherapy based on cisplatin 40 mg/m and the addition of a stereotactic radiosurgery boost were administered. The tolerance of this treatment was acceptable. During the 2-year follow-up, local and distant recurrences were not diagnosed. The presented case shows the usefulness of an individualized approach in the radical treatment of sebaceous carcinoma with the use of the stereotactic radiotherapy boost. This is a subsequent example of the implementation of the boost in head and neck carcinoma, which yields a positive result.
皮脂腺癌是一种罕见的恶性肿瘤，应采用手术切除治疗。尽管如此，该疾病动态且侵袭性的病程可能使患者不适合这种治疗。采用立体定向增敏技术递增剂量进行放射治疗作为一种根治性治疗方法值得考虑。在本文中，我们展示了一名肿瘤位于眼周区域的年轻患者的病例研究。该患者接受了两次手术，但效果均不理想。给予了常规放疗，30次分割共60 Gy，并联合基于顺铂40 mg/m²的化疗以及立体定向放射外科增敏治疗。这种治疗的耐受性是可以接受的。在2年的随访期间，未诊断出局部和远处复发。该病例展示了在皮脂腺癌根治性治疗中采用立体定向放疗增敏的个体化方法的有效性。这是头颈部癌实施增敏治疗取得阳性结果的又一个例子。
