Department of Immunology and Biotechnology, Medical School, University of Pecs, H-7624 Pécs, Hungary.
Lymphoid Organogenesis Research Group, Szentagothai Research Center, University of Pecs, H-7624 Pécs, Hungary.
Int J Mol Sci. 2023 Jun 6;24(12):9809. doi: 10.3390/ijms24129809.
The natural autoantibody (natAAb) network is thought to play a role in immune regulation. These IgM antibodies react with evolutionary conserved antigens; however, they do not lead to pathological tissue destruction as opposed to pathological autoantibodies (pathAAb). The exact relation between the natAAbs and pathAAbs is still not completely understood; therefore, in the present study, we set out to measure nat- and pathAAb levels against three conserved antigens in a spontaneous autoimmune disease model: the NZB mouse strain which develops autoimmune hemolytic anemia (AIHA) from six months of age. There was an age dependent increase in the natAAb levels in the serum against Hsp60, Hsp70, and the mitochondrial citrate synthase until 6-9 months of age, followed by a gradual decrease. The pathological autoantibodies appeared after six months of age, which corresponded with the appearance of the autoimmune disease. The changes in nat/pathAAb levels were coupled with decreasing B1- and increasing plasma cell and memory B cell percentages. Based on this, we propose that there is a switch from natAAbs towards pathAAbs in aged NZB mice.
天然自身抗体 (natAAb) 网络被认为在免疫调节中发挥作用。这些 IgM 抗体与进化上保守的抗原发生反应；然而，它们不会像病理性自身抗体 (pathAAb) 那样导致病理性组织破坏。natAAbs 和 pathAAbs 之间的确切关系仍不完全清楚；因此，在本研究中，我们着手测量三种保守抗原在自发性自身免疫疾病模型中的 nat- 和 pathAAb 水平：从六个月大开始发展自身免疫性溶血性贫血 (AIHA) 的 NZB 小鼠品系。针对 Hsp60、Hsp70 和线粒体柠檬酸合酶的血清 natAAb 水平随年龄呈依赖性增加，直至 6-9 个月大，随后逐渐下降。病理性自身抗体在六个月大后出现，与自身免疫性疾病的出现相对应。nat/pathAAb 水平的变化伴随着 B1 细胞的减少和浆细胞和记忆 B 细胞百分比的增加。基于此，我们提出在老年 NZB 小鼠中存在从 natAAb 向 pathAAb 的转变。
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