Laboratório de Doenças Autoimunes, Divisão de Reumatologia, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350, sala 12109, Porto Alegre, 90035-003, Brazil.
Programa de Pós-Graduação em Medicina: Ciências Médicas, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Clin Rheumatol. 2021 Jul;40(7):2535-2545. doi: 10.1007/s10067-020-05493-7. Epub 2020 Nov 6.
Systemic lupus erythematosus (SLE) that involves neurological complications is known as neuropsychiatric systemic lupus erythematosus (NPSLE). Research in humans is difficult due to the disease's great heterogeneity. Animal models are a resource for new discoveries. In this review, we examine experimental models of lupus that present neuropsychiatric manifestations. Spontaneous animal models such as NZB/W F1 and MRL/lpr are commonly used in NPSLE research; these models present few SLE symptoms compared to induced animal models, such as pristane-induced lupus (PIL). The PIL model is known to present eight of the main clinical and laboratory manifestations of SLE described by the American College of Rheumatology. Many cytokines associated with NPSLE are expressed in the PIL model, such as IL-6, TNF-α, and IFN. However, to date, NPSLE manifestations have been poorly studied in the PIL model. In this review article, we discuss whether the PIL model can mimic neuropsychiatric manifestations of SLE. Key Points • PIL model have a strong interferon signature. • Animals with PIL express learning and memory deficit.
系统性红斑狼疮（SLE）累及神经系统并发症称为神经精神性系统性红斑狼疮（NPSLE）。由于该疾病具有高度异质性，因此人类的研究非常困难。动物模型是新发现的资源。在这篇综述中，我们研究了具有神经精神表现的狼疮实验模型。自发性动物模型，如 NZB/W F1 和 MRL/lpr，常用于 NPSLE 研究；与诱导性动物模型（如 pristane 诱导性狼疮（PIL））相比，这些模型的 SLE 症状较少。PIL 模型已知表现出美国风湿病学会描述的 SLE 的八种主要临床和实验室表现。许多与 NPSLE 相关的细胞因子在 PIL 模型中表达，如 IL-6、TNF-α 和 IFN。然而，迄今为止，PIL 模型中对 NPSLE 表现的研究还很少。在这篇综述文章中，我们讨论了 PIL 模型是否可以模拟 SLE 的神经精神表现。 关键点 • PIL 模型具有强烈的干扰素特征。 • 患有 PIL 的动物表现出学习和记忆缺陷。
