Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego Str. 13, 10-718 Olsztyn, Poland.
Int J Mol Sci. 2023 Jun 7;24(12):9871. doi: 10.3390/ijms24129871.
Aspirin (ASA) is a popular nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic properties through the inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA results in the formation of gastrointestinal side effects. Due to the fact that the enteric nervous system (ENS) is involved in the regulation of digestive functions both in physiological and pathological states, the aim of this study was to determine the influence of ASA on the neurochemical profile of enteric neurons in the porcine duodenum. Our research, conducted using the double immunofluorescence technique, proved an increase in the expression of selected enteric neurotransmitters in the duodenum as a result of ASA treatment. The mechanisms of the visualized changes are not entirely clear but are probably related to the enteric adaptation to inflammatory conditions resulting from aspirin supplementation. A detailed understanding of the role of the ENS in the development of drug-induced inflammation will contribute to the establishment of new strategies for the treatment of NSAID-induced lesions.
阿司匹林（ASA）是一种流行的非甾体抗炎药（NSAID），通过抑制环氧化酶（COX）同工酶 2（COX-2）发挥其治疗特性，而 ASA 对 COX-1 的抑制导致胃肠道副作用的形成。由于肠神经系统（ENS）参与生理和病理状态下消化功能的调节，本研究旨在确定 ASA 对猪十二指肠肠神经元神经化学特征的影响。我们的研究使用双重免疫荧光技术证明，ASA 治疗会导致十二指肠中选定的肠神经递质表达增加。所观察到的变化的机制尚不完全清楚，但可能与肠对阿司匹林补充引起的炎症条件的适应有关。详细了解 ENS 在药物引起的炎症发展中的作用将有助于为治疗 NSAID 引起的损伤制定新的策略。
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