Department of Sense Organs, Sapienza University of Rome, 00161 Rome, Italy.
Ophthalmology Unit, Neurosciences, Mental Health, and Sensory Organs (NESMOS) Department, Sapienza University of Rome, Via di Grottarossa 1035/1039, 00189 Rome, Italy.
Int J Mol Sci. 2023 Jun 15;24(12):10167. doi: 10.3390/ijms241210167.
Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller's layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.
糖尿病性脉络膜病变首先在糖尿病眼的组织病理学标本中被描述。这种改变的特征是在毛细血管基质内积聚 PAS 阳性物质。炎症和多形核中性粒细胞(PMN)的激活是脉络膜毛细血管损伤的关键因素。糖尿病性脉络膜病变的活体证据通过多模态成像得到了证实,该成像提供了关键的定量和定性特征来描述脉络膜的受累情况。脉络膜可以在每个血管层中受到影响,从 Haller 层到脉络膜毛细血管。然而,外层视网膜和光感受器细胞的损伤主要是由脉络膜毛细血管缺陷引起的,这可以通过光相干断层扫描血管造影(OCTA)来评估。识别糖尿病性脉络膜病变的特征对于理解糖尿病性视网膜病变中的潜在发病机制和预后意义具有重要意义。