Wuxi Medical College, Jiangnan University, Wuxi 214000, China.
Department of Oncology, The Affiliated Hospital of Jiangnan University, Wuxi 214000, China.
Medicina (Kaunas). 2023 Jun 12;59(6):1133. doi: 10.3390/medicina59061133.
We aimed to investigate the role of expression in colorectal cancer (CRC) prognosis and evaluate its potential as a therapeutic target in -mutated CRC. : Exactly 136 samples of formalin-fixed paraffin-embedded CRC tissue specimens were obtained from patients who underwent surgical resection for CRC. The gene mutation status of the samples was detected using fluorescence PCR. expression was detected using immunohistochemistry. Survival curves with high expression and mutations were compared using the Kaplan-Meier method. A nomogram was constructed to determine the estimated overall survival probability. We also predicted the 3-year and 5-year survival rates for patients with high expression and mutations. In total, 50 samples of -mutated CRC were collected and detected expression by immunohistochemistry. The Chi-squared test was used to analyze the association between expression and -mutated CRC. : High expression and mutations are associated with poor prognosis of CRC. Multivariate survival analyses indicated that high expression and mutations are significant independent predictors of CRC prognosis. Furthermore, high expression was significantly associated with -mutated CRC, and may be a potential therapeutic target for -mutated CRC. : High expression confers poor prognosis in colorectal cancer and represents a novel therapeutic target in -mutated CRC.
我们旨在探讨在结直肠癌（CRC）中的作用，并评估其作为-突变 CRC 治疗靶点的潜力。：从接受 CRC 手术切除的患者中获得了 136 例福尔马林固定石蜡包埋的 CRC 组织标本。使用荧光 PCR 检测样本的基因突变状态。使用免疫组织化学检测 表达。使用 Kaplan-Meier 方法比较高 表达和 突变的生存曲线。构建列线图以确定估计的总生存率。我们还预测了高 表达和 突变患者的 3 年和 5 年生存率。共收集 50 例-突变 CRC 样本，并通过免疫组织化学检测 表达。使用卡方检验分析 表达与-突变 CRC 之间的关系。：高 表达和 突变与 CRC 的不良预后相关。多变量生存分析表明，高 表达和 突变是 CRC 预后的显著独立预测因子。此外，高 表达与-突变 CRC 显著相关，可能是-突变 CRC 的潜在治疗靶点。：高 表达赋予结直肠癌不良预后，代表-突变 CRC 的新型治疗靶点。
