Moscoso G J, Driver M, Guy R J
Pathol Res Pract. 1986 May;181(2):188-94. doi: 10.1016/S0344-0338(86)80009-7.
Pathological changes identified in the muscular wall of the stomach from two young insulin-dependent diabetic patients suffering from severe gastric autonomic neuropathy are presented. Scattered smooth muscle cells appearing as homogeneous round eosinophilic bodies ("M" bodies) among areas of sub-total smooth muscle cell atrophy together with intercellular collagen proliferation were identified in the muscularis propria of the stomach. Ultrastructurally, the "M" bodies are transformed smooth muscle cells undergoing a form of necrobiosis with peculiar intracellular features. These changes appear characteristic of end-stage diabetic gastric autonomic neuropathy when compared with other pathological conditions involving the gastric wall. The degree and extent of involvement of the various components of the gastric wall are discussed.
本文呈现了两名患有严重胃自主神经病变的年轻胰岛素依赖型糖尿病患者胃肌壁中所发现的病理变化。在胃固有肌层中，发现散在的平滑肌细胞呈现为均匀的圆形嗜酸性小体（“M”小体），位于平滑肌细胞部分萎缩区域之间，同时伴有细胞间胶原增生。超微结构显示，“M”小体是正在经历一种具有特殊细胞内特征的渐进性坏死的转化平滑肌细胞。与涉及胃壁的其他病理状况相比，这些变化似乎是终末期糖尿病胃自主神经病变的特征。文中还讨论了胃壁各组成部分受累的程度和范围。
