双吡啶钌（II）配合物与卤素取代水杨酸酯：合成、晶体结构和生物活性。
Bipyridine Ruthenium(II) Complexes with Halogen-Substituted Salicylates: Synthesis, Crystal Structure, and Biological Activity.
机构信息
Department of Inorganic Chemistry, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
Department of Materials Chemistry, Institute of Inorganic Chemistry of the CAS, Husinec-Řež č.p. 1001, 250 68 Řež, Czech Republic.
出版信息
Molecules. 2023 Jun 7;28(12):4609. doi: 10.3390/molecules28124609.
Ruthenium complexes currently represent a perspective subject of investigation in terms of potential anticancer therapeutics. Eight novel octahedral ruthenium(II) complexes are the subject of this article. Complexes contain 2,2'-bipyridine molecules and salicylates as ligands, differing in position and type of halogen substituent. The structure of the complexes was determined via X-ray structural analysis and NMR spectroscopy. All complexes were characterized by spectral methods-FTIR, UV-Vis, ESI-MS. Complexes show sufficient stability in solutions. Therefore, their biological properties were studied. Binding ability to BSA, interaction with DNA, as well as in vitro antiproliferative effects against MCF-7 and U-118MG cell lines were investigated. Several complexes showed anticancer effects against these cell lines.
钌配合物目前是癌症治疗潜在药物的研究热点。本文研究了 8 种新型八面体钌（II）配合物。这些配合物包含 2,2'-联吡啶分子和水杨酸盐作为配体，配体的卤原子取代基在位置和类型上有所不同。配合物的结构通过 X 射线结构分析和 NMR 光谱确定。所有配合物均通过光谱方法-FTIR、UV-Vis、ESI-MS 进行了表征。配合物在溶液中具有足够的稳定性。因此，研究了它们的生物学特性。研究了它们与 BSA 的结合能力、与 DNA 的相互作用以及对 MCF-7 和 U-118MG 细胞系的体外增殖抑制作用。一些配合物对这些细胞系表现出抗癌作用。
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