Key Laboratory for Zhuang and Yao Pharmaceutical Quality Biology, School of Food and Biochemical Engineering, Guangxi Science & Technology Normal University, Laibin 546199, China.
Molecules. 2023 Jun 20;28(12):4876. doi: 10.3390/molecules28124876.
Developing a new generation of anticancer metal-based drugs that can both kill tumor cells and inhibit cell migration is a promising strategy. Herein, we synthesized three Cu(II), Zn(II), and Mn(II) complexes derived from 5-chloro-2--(2-quinolylmethylene)aminophenol (C1-C3). Among these complexes, the Cu(II) complex (C1) showed significantly greater cytotoxicity toward lung cancer cell lines than cisplatin. C1 inhibited A549 cell metastasis and suppressed the growth of the A549 tumor in vivo. In addition, we confirmed the anticancer mechanism of C1 by triggering multiple mechanisms, including inducing mitochondrial apoptosis, acting on DNA, blocking cell cycle arrest, inducing cell senescence, and inducing DNA damage.
开发既能杀死肿瘤细胞又能抑制细胞迁移的新一代基于金属的抗癌药物是一种很有前途的策略。在此，我们合成了三种由 5-氯-2-（2-喹啉亚甲基）氨基苯酚（C1-C3）衍生的 Cu(II)、Zn(II) 和 Mn(II) 配合物。在这些配合物中，Cu(II)配合物（C1）对肺癌细胞系的细胞毒性明显大于顺铂。C1 抑制 A549 细胞转移，并抑制体内 A549 肿瘤的生长。此外，我们通过触发多种机制，包括诱导线粒体凋亡、作用于 DNA、阻断细胞周期停滞、诱导细胞衰老和诱导 DNA 损伤，证实了 C1 的抗癌机制。
