Grenda Tomasz, Jarosz Aleksandra, Sapała Magdalena, Grenda Anna, Patyra Ewelina, Kwiatek Krzysztof
Department of Hygiene of Animal Feeding Stuffs, National Veterinary Research Institute in Pulawy, Partyzantow 57, 24-100 Pulawy, Poland.
Department of Pneumonology, Oncology and Allergology, Medical University in Lublin, Jaczewskiego 8, 20-950 Lublin, Poland.
Pathogens. 2023 May 26;12(6):768. doi: 10.3390/pathogens12060768.
The species is associated with various environments, such as soils, sewage, and food. However, it is also a component of the gastrointestinal (GI) microflora (i.e., microbiota) of sick and healthy humans and animals. is linked with different systemic and enteric diseases in livestock and humans, such as gas gangrene, food poisoning, non-foodborne diarrhoea, and enterocolitis. The strains of this opportunistic pathogen are known to secrete over 20 identified toxins that are considered its principal virulence factors. belongs to the anaerobic bacteria community but can also survive in the presence of oxygen. The short time between generations, the multi-production capability of toxins and heat-resistant spores, the location of many virulence genes on mobile genetic elements, and the inhabitance of this opportunistic pathogen in different ecological niches make a very important microorganism for public health protection. The epidemiological evidence for the association of these strains with -meditated food poisoning and some cases of non-foodborne diseases is very clear and well-documented. However, the genetic diversity and physiology of should still be studied in order to confirm the importance of suspected novel virulence traits. A very significant problem is the growing antibiotic resistance of strains. The aim of this review is to show the current basic information about the toxins, epidemiology, and genetic and molecular diversity of this opportunistic pathogen.
该物种与多种环境相关,如土壤、污水和食物。然而,它也是患病和健康的人类及动物胃肠道微生物群(即微生物区系)的组成部分。它与家畜和人类的不同全身性和肠道疾病有关,如气性坏疽、食物中毒、非食源性腹泻和小肠结肠炎。已知这种机会致病菌的菌株能分泌20多种已鉴定的毒素,这些毒素被认为是其主要毒力因子。它属于厌氧细菌群落,但也能在有氧环境中存活。世代间隔时间短、毒素的多种产生能力和耐热孢子、许多毒力基因位于可移动遗传元件上以及这种机会致病菌在不同生态位中的栖息,使其成为公共卫生防护中非常重要的微生物。这些菌株与介导的食物中毒和一些非食源性疾病病例之间关联的流行病学证据非常明确且记录充分。然而,仍应研究该菌的遗传多样性和生理学,以确认可疑新毒力特征的重要性。一个非常严重的问题是该菌菌株的抗生素耐药性不断增强。本综述的目的是展示关于这种机会致病菌的毒素、流行病学以及遗传和分子多样性的当前基本信息。