Thoma K, Heckenmüller H
Pharmazie. 1986 May;41(5):328-32.
Softeners in enteric coatings as phthalic acid esters, citric acid esters, tartaric acid esters, glycerine esters, alcohols or surfactants can be identified by thin layer chromatography. Normally they are extracted by ether out of a phosphate buffer solution of the coating. In exceptional cases, it is necessary to extract dry isolated enteric coatings with acetone/ethanol. As developing solvents butanol and methylene-chloride are recommended. To separate similar substances as glycerine-diacetate from glycerine-triacetate it can be necessary to evaluate the results in both developing solvents. Softeners had been isolated and identified from 9 examples of commercial drugs.
肠溶包衣中的软化剂，如邻苯二甲酸酯、柠檬酸酯、酒石酸酯、甘油酯、醇类或表面活性剂，可用薄层色谱法进行鉴定。通常情况下，它们用乙醚从包衣的磷酸盐缓冲溶液中萃取出来。在特殊情况下，有必要用丙酮/乙醇萃取干燥的分离肠溶包衣。推荐使用正丁醇和二氯甲烷作为展开剂。为了将甘油二乙酸酯等类似物质与甘油三乙酸酯分离，可能需要在两种展开剂中评估结果。已从9种商业药物样品中分离并鉴定出软化剂。
