Peix Amalia, Perez Aylen, Barreda Ana Maria
Nuclear Medicine Department, Institute of Cardiology and Cardiovascular Surgery Havana, Cuba.
Radiology Department, Institute of Cardiology and Cardiovascular Surgery Havana, Cuba.
Eur Cardiol. 2023 Mar 29;18:e08. doi: 10.15420/ecr.2022.36. eCollection 2023.
Cancer and cardiovascular disease are the two main causes of death worldwide in both men and women. In the past decades, survival rate in cancer patients has substantially improved due to new treatments and developments in radiation therapy (RT). In women, breast cancer (BC) is the leading cause of cancer death and thoracic RT is a main component of the treatment in many cases. Nevertheless, despite new techniques that limit the area receiving RT, cardiac damage is still an important concern in BC patients. In this review, the following aspects will be addressed: pathophysiology of postradiotherapy heart damage in women with BC; mechanisms, diagnosis and prevention/management of heart damage; and future areas of potential research for radiotherapy injury in women.
癌症和心血管疾病是全球男性和女性死亡的两大主要原因。在过去几十年中，由于新的治疗方法以及放射治疗（RT）的发展，癌症患者的生存率有了显著提高。在女性中，乳腺癌（BC）是癌症死亡的主要原因，在许多情况下，胸部放疗是治疗的主要组成部分。然而，尽管有新技术可限制接受放疗的区域，但心脏损伤仍是乳腺癌患者的一个重要问题。在本综述中，将探讨以下几个方面：乳腺癌女性放疗后心脏损伤的病理生理学；心脏损伤的机制、诊断和预防/管理；以及女性放疗损伤潜在研究的未来领域。
