School of Pharmacy and Henan Province Engineering Research Center of High Value Utilization to Natural Medical Resource in Yellow River Basin, Henan University, Kaifeng, Henan, 475004, People's Republic of China.
Medical school, Henan Technical Institute, Kaifeng, Henan, 475004, People's Republic of China.
Int J Nanomedicine. 2023 Jun 22;18:3407-3428. doi: 10.2147/IJN.S408416. eCollection 2023.
Hepatoma is the leading cause of death among liver diseases worldwide. Modern pharmacological studies suggest that some natural monomeric compounds have a significant effect on inhibiting tumor growth. However, poor stability and solubility, and side effects are the main factors limiting the clinical application of natural monomeric compounds.
In this paper, drug-co-loaded nanoself-assemblies were selected as a delivery system to improve the chemical stability and solubility of Tanshinone II A and Glycyrrhetinic acid, and to produce a synergetic anti-hepatoma effect.
The study suggested that the drug co-loaded nanoself-assemblies showed high drug loading capacity, good physical and chemical stability, and controlled release. In vitro cell experiments verified that the drug-co-loaded nanoself-assemblies could increase the cellular uptake and cell inhibitory activity. In vivo studies verified that the drug co-loaded nanoself-assemblies could prolong the MRT, increase accumulation in tumor and liver tissues, and show strong synergistic anti-tumor effect and good bio-safety in H22 tumor-bearing mice.
This work indicates that natural monomeric compounds co-loaded nanoself-assemblies would be a potential strategy for the treatment of hepatoma.
肝癌是全球范围内导致肝脏疾病死亡的主要原因。现代药理学研究表明，一些天然单体化合物对抑制肿瘤生长具有显著作用。然而，较差的稳定性和溶解度以及副作用是限制天然单体化合物临床应用的主要因素。
本文选择载药纳米自组装体作为一种给药系统，以提高丹参酮 IIA 和甘草酸的化学稳定性和溶解度，并产生协同的抗肝癌作用。
研究表明，载药纳米自组装体具有高载药能力、良好的物理化学稳定性和控制释放性。体外细胞实验验证了载药纳米自组装体可以增加细胞摄取和细胞抑制活性。体内研究验证了载药纳米自组装体可以延长 MRT，增加肿瘤和肝脏组织中的蓄积，并在 H22 荷瘤小鼠中表现出强烈的协同抗肿瘤作用和良好的生物安全性。
这项工作表明，天然单体化合物共载纳米自组装体可能是治疗肝癌的一种有潜力的策略。
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