无胸腺裸鼠体内大鼠肿瘤异种移植生长的血清学方面
Serological aspects of rat tumour xenograft growth in athymic nude mice.
作者信息
Pimm M V, Baldwin R W
出版信息
Br J Cancer. 1979 Feb;39(2):116-21. doi: 10.1038/bjc.1979.21.
Abstract
The serum of athymic nude mice bearing rat tumour xenografts has been examined for tumour-specific antigen. With a sarcoma and a hepatoma, tumour-specific antigen expression continued in xenograft growths, and sera of tumour-bearing mice contained free antigen, assayed by its ability to neutralise reactivity of tumour-immune rat sera against tumour target cells in an indirect membrane-immunofluorescence test. In contrast, no anti-rat antibody was detectable in sera of mice bearing the xenografts, or rejecting cells injected in admixture with BCG.
摘要
已对携带大鼠肿瘤异种移植物的无胸腺裸鼠血清进行了肿瘤特异性抗原检测。对于肉瘤和肝癌，在异种移植物生长过程中肿瘤特异性抗原持续表达，通过在间接膜免疫荧光试验中中和肿瘤免疫大鼠血清对肿瘤靶细胞的反应性能力测定，荷瘤小鼠血清中含有游离抗原。相比之下，在携带异种移植物的小鼠血清中或排斥与卡介苗混合注射细胞的小鼠血清中未检测到抗大鼠抗体。
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