慢性肾脏病和自我认知障碍的老年患者的睡眠与大脑功能之间的关系。
The Relationship Between Sleep and Brain Function in Older Adults With Chronic Kidney Disease and Self-Identified Cognitive Impairment.
出版信息
J Gerontol Nurs. 2023 Jul;49(7):31-39. doi: 10.3928/00989134-20230616-01. Epub 2023 Jul 1.
Older adults with chronic kidney disease (CKD) are at risk for cognitive impairment and sleep disturbances. The purpose of the current study was to investigate the relationship between sleep and brain structure/function in older adults with CKD and self-identified cognitive impairment. The sample ( = 37) had a mean age of 68 years ( = 4.9 years), estimated glomerular filtration rate of 43.7 mL/min/1.73m ( = 10.98), median sleep time of 7.4 hours, and was 70% female. Sleeping <7.4 hours, compared to ≥7.4 hours, was associated with better attention/information processing (β = 11.46, 95% confidence interval [CI] [3.85, 19.06]) and better learning/memory (β = 2.06, 95% CI [0.37, 3.75]). Better sleep efficiency was associated with better global cerebral blood flow (β = 3.30, 95% CI [0.65, 5.95]). Longer awake length after sleep onset was associated with worse fractional anisotropy of the cingulum (β = -0.01, 95% CI [-0.02, -0.003]). Sleep duration and continuity may be related to brain function in older adults with CKD and self-identified cognitive impairment. [(7), 31-39.].
患有慢性肾脏病（CKD）的老年人存在认知障碍和睡眠障碍的风险。本研究的目的是调查患有 CKD 和自我认定认知障碍的老年人睡眠与大脑结构/功能之间的关系。样本（n=37）的平均年龄为 68 岁（=4.9 岁），估算肾小球滤过率为 43.7 mL/min/1.73m（=10.98），中位睡眠时间为 7.4 小时，女性占 70%。与睡眠时间<7.4 小时相比，睡眠时间≥7.4 小时与更好的注意力/信息处理能力（β=11.46，95%置信区间[CI] [3.85，19.06]）和更好的学习/记忆能力（β=2.06，95% CI [0.37，3.75]）相关。更好的睡眠效率与更好的全脑血流（β=3.30，95% CI [0.65，5.95]）相关。睡眠起始后清醒时间延长与扣带束各向异性分数降低有关（β=-0.01，95% CI [-0.02，-0.003]）。睡眠持续时间和连续性可能与患有 CKD 和自我认定认知障碍的老年人的大脑功能有关。[(7), 31-39]。
Zotero 插件