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磁性氧化铁纳米颗粒对细胞和细胞外囊泡影响的最新进展

Recent progress in the effect of magnetic iron oxide nanoparticles on cells and extracellular vesicles.

作者信息

Chen Yuling, Hou Shike

机构信息

Institute of Disaster and Emergency Medicine, Tianjin University, 300072, Tianjin, China.

Key Laboratory for Disaster Medicine Technology, 300072, Tianjin, China.

出版信息

Cell Death Discov. 2023 Jun 28;9(1):195. doi: 10.1038/s41420-023-01490-2.

DOI:10.1038/s41420-023-01490-2
PMID:37380637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10307851/
Abstract

At present, iron oxide nanoparticles (IONPs) are widely used in the biomedical field. They have unique advantages in targeted drug delivery, imaging and disease treatment. However, there are many things to pay attention to. In this paper, we reviewed the fate of IONPs in different cells and the influence on the production, separation, delivery and treatment of extracellular vesicles. It aims to provide cutting-edge knowledge related to iron oxide nanoparticles. Only by ensuring the safety and effectiveness of IONPs can their application in biomedical research and clinic be further improved.

摘要

目前，氧化铁纳米颗粒（IONPs）在生物医学领域得到广泛应用。它们在靶向药物递送、成像和疾病治疗方面具有独特优势。然而，有许多需要注意的事项。在本文中，我们综述了IONPs在不同细胞中的命运以及对细胞外囊泡的产生、分离、递送和治疗的影响。旨在提供与氧化铁纳米颗粒相关的前沿知识。只有确保IONPs的安全性和有效性，才能进一步推动其在生物医学研究和临床中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/249b/10307851/26a2c00a3d7a/41420_2023_1490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/249b/10307851/26a2c00a3d7a/41420_2023_1490_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/249b/10307851/26a2c00a3d7a/41420_2023_1490_Fig1_HTML.jpg

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本文引用的文献

[1]
Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer.

Natl Sci Rev. 2022-8-18

[2]
Iron Oxide Nanoparticle-Incorporated Mesenchymal Stem Cells for Alzheimer's Disease Treatment.

Nano Lett. 2023-1-25

[3]
Magneto-mechanical destruction of cancer-associated fibroblasts using ultra-small iron oxide nanoparticles and low frequency rotating magnetic fields.

Nanoscale Adv. 2021-11-18

[4]
p53 Promotes Ferroptosis in Macrophages Treated with FeO Nanoparticles.

ACS Appl Mater Interfaces. 2022-9-28

[5]
Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway.

Mater Today Bio. 2022-6-11

[6]
Impact of Surface Chemistry of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles on Protein Corona Formation and Endothelial Cell Uptake, Toxicity, and Barrier Function.

Toxicol Sci. 2022-7-28

[7]
Tetraspanins distinguish separate extracellular vesicle subpopulations in human serum and plasma - Contributions of platelet extracellular vesicles in plasma samples.

J Extracell Vesicles. 2022-5

[8]
Hedgehog-inspired immunomagnetic beads for high-efficient capture and release of exosomes.

J Mater Chem B. 2022-6-1

[9]
Extracellular Vesicle-Mediated Delivery of Ultrasmall Superparamagnetic Iron Oxide Nanoparticles to Mice Brain.

Front Pharmacol. 2022-4-7

[10]
Effects of Magnetite Nanoparticles and Static Magnetic Field on Neural Differentiation of Pluripotent Stem Cells.

Stem Cell Rev Rep. 2022-4

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