Wu Li, Wang Chunting, Li Yu
College of Medical Imaging, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.
Department of Radiology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, 519000, China.
Nanomedicine (Lond). 2022 Sep;17(21):1567-1583. doi: 10.2217/nnm-2022-0246. Epub 2022 Dec 2.
Iron oxide nanoparticles (IONPs) can be applied to targeted drug delivery, targeted diagnosis and treatment of tumors due to their easy preparation, good biocompatibility, low biotoxicity, high imaging quality, high magnetothermal sensitivity and stable targeting after certain surface modifications. However, the complexity of the mechanism of action and their properties has led to there being few clinical applications of IONPs. This review first describes the targeting mechanisms of IONPs and their toxicity issues, then discusses the applications of IONP targeting studies in tumor MRI. Finally, the applications of IONP targeting in tumor therapy are listed. The authors show the advantages of targeting IONPs and hope that the review will increase the possibility of converting IONPs from biomedical applications to clinical applications.
氧化铁纳米颗粒（IONPs）由于其易于制备、良好的生物相容性、低生物毒性、高成像质量、高磁热敏感性以及在经过一定表面修饰后具有稳定的靶向性，可应用于靶向药物递送、肿瘤的靶向诊断与治疗。然而，其作用机制和性质的复杂性导致IONPs在临床上的应用较少。本综述首先描述了IONPs的靶向机制及其毒性问题，然后讨论了IONP靶向研究在肿瘤磁共振成像（MRI）中的应用。最后，列举了IONP靶向在肿瘤治疗中的应用。作者展示了IONPs靶向的优势，并希望本综述能增加将IONPs从生物医学应用转化为临床应用的可能性。
