评估葡聚糖对大鼠肝脏、肾脏和乳腺肿瘤发生的影响。
Evaluation of the effect of glucan on hepatic, renal and mammary tumorigenesis in rats.
作者信息
Porta E A, Dytioco S, Aquino T, Dorado R D, Ooka S, Markell N
出版信息
Res Commun Chem Pathol Pharmacol. 1986 Jun;52(3):391-4.
Glucan was evaluated for its ability to modify the hepatic and renal tumorigenesis induced in partially hepatectomized Sprague-Dawley female rats by diethylnitrosamine (DEN) and phenobarbital (PB), and the mammary tumorigenesis induced in intact Sprague-Dawley female rats by N-nitrosomethylurea (NMU). In both models the rats received every two weeks i.v. glucan (10 mg/kg) or equivalent amounts of dextrose. The results indicated that glucan did not significantly modify the incidence of the chemically-induced hepatic, renal and mammary tumors.
对葡聚糖进行了评估，观察其对部分肝切除的Sprague-Dawley雌性大鼠由二乙基亚硝胺（DEN）和苯巴比妥（PB）诱导的肝和肾肿瘤发生，以及对未切除的Sprague-Dawley雌性大鼠由N-亚硝基甲脲（NMU）诱导的乳腺肿瘤发生的影响。在这两种模型中，大鼠每两周静脉注射葡聚糖（10毫克/千克）或等量的葡萄糖。结果表明，葡聚糖并未显著改变化学诱导的肝、肾和乳腺肿瘤的发生率。
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