三种与 A 型肉毒神经毒素和神经元有关的“毒性关系”。
Three players in the 'toxic affair' between botulinum neurotoxin type A and neurons.
机构信息
Department of Biomedical Sciences, University of Padova, Padova, Italy; Consiglio Nazionale delle Ricerche, Institute of Neuroscience, University of Padova, Padova, Italy.
Department of Biomedical Sciences, University of Padova, Padova, Italy.
出版信息
Trends Neurosci. 2023 Sep;46(9):695-697. doi: 10.1016/j.tins.2023.06.001. Epub 2023 Jun 27.
Joensuu and colleagues have recently shown that botulinum neurotoxin (BoNT) type A exploits a heterotrimeric complex in the presynaptic membrane to bind to and enter neurons using a Trojan horse-like mechanism. Similar processes may be relevant to the neuronal entry of different botulinum toxin serotypes and other neuropathogens.
约恩苏和同事们最近表明，A型肉毒毒素（BoNT）利用突触前膜中的三聚体复合物，通过类似特洛伊木马的机制结合并进入神经元。类似的过程可能与不同型别的肉毒毒素和其他神经病原体进入神经元有关。
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