安非他酮过量导致的癫痫发作及其他严重后果：近期病例报告与已发表病例综述
Seizure and Other Catastrophes due to Bupropion Overdose: Recent Case Report and Review of Published Cases.
作者信息
Snehal Isha, Lorenzen Garret, Sharma Ashish
机构信息
Dr. Snehal is with Department of Neurological Sciences, University of Nebraska Medical Center in Omaha, Nebraska.
Mr. Lorenzen is with College of Medicine, University of Nebraska Medical Center in Omaha, Nebraska.
出版信息
Innov Clin Neurosci. 2023 Spring;20(4-6):49-52.
Bupropion has been in use for several decades. It is widely used for major depressive disorder (MDD), seasonal affective disorder (SAD), and smoking cessation. It is also a treatment of choice for mild-to-moderate depression and is prescribed for atypical and melancholic depression. However, bupropion overdose can lead to serious neurological and cardiovascular adverse effects. We report a recent case of bupropion overdose and review published cases in the literature to present the spectrum of clinical findings and treatments used to overcome the effects of bupropion overdose. Per our findings, bupropion doses of 2.7g and upward can lead to seizures and cause encephalopathy and cardiovascular effects. Higher doses could also lead to intubation and increased hospital stay. Therefore, patients with an increased risk of cardiovascular issues and seizures should be evaluated before starting the medication or increasing the dosage.
安非他酮已使用了几十年。它被广泛用于治疗重度抑郁症（MDD）、季节性情感障碍（SAD）和戒烟。它也是轻至中度抑郁症的首选治疗药物，常用于治疗非典型抑郁症和 melancholic 抑郁症。然而，安非他酮过量可导致严重的神经和心血管不良反应。我们报告了一例近期安非他酮过量病例，并回顾了文献中已发表的病例，以展示临床发现的范围以及用于克服安非他酮过量影响的治疗方法。根据我们的研究结果，2.7克及以上的安非他酮剂量可导致癫痫发作，并引起脑病和心血管效应。更高的剂量还可能导致插管和住院时间延长。因此，在开始用药或增加剂量之前，应对心血管问题和癫痫发作风险增加的患者进行评估。
Zotero 插件