Makarovskiĭ V V, Sumarokov A V
Ter Arkh. 1986;58(5):41-8.
Serial investigations of the activity of cardiospecific enzymes in the blood allowed one to reveal a prolonged type of a dynamic curve "enzymatic activity-time" characterized by two or more peaks in 66.7% of patients with the acute phase of myocardial infarction. It was assumed that such a curve type could be determined by the formation of multiple necrotic foci in the myocardium. A close correlation between the rate of increment and peak activity of the LDH, CPK and MB-CPK was shown. These and other parameters of the blood enzymogram in the acute phase of myocardial infarction made it possible to assess the development of a necrotic process in the myocardium and, consequently, a clinical course of disease.
对血液中心肌特异性酶活性进行系列研究，使得人们能够在66.7%的急性心肌梗死患者中发现一种延长型的动态曲线“酶活性-时间”，其特征为出现两个或更多个峰值。据推测，这种曲线类型可能由心肌中多个坏死灶的形成所决定。研究显示乳酸脱氢酶（LDH）、肌酸磷酸激酶（CPK）和肌酸磷酸激酶同工酶MB（MB-CPK）的增量速率与峰值活性之间存在密切相关性。急性心肌梗死急性期血液酶谱的这些及其他参数，使得评估心肌坏死过程的发展以及疾病的临床进程成为可能。
