Trinh Anh Ngoc, Nguyen Kim Han, Nguyen Dinh Van
Internal Medicine Department, Vinmec Healthcare System, Hanoi, Vietnam.
College of Health Sciences, VinUniversity, Hanoi, Vietnam.
Asia Pac Allergy. 2023 Mar;13(1):54-56. doi: 10.5415/apallergy.0000000000000023. Epub 2023 Apr 28.
We present hyperthyroidism with autoimmune thyroid disease, which developed a few weeks after the COVID-19 infection in a patient with no prior thyroid disease. Our case was described with clinical presentations, diagnostic tests, and subsequent patient management and compared to other similar reported cases. A 28-year-old female patient with no prior history of thyroid dysfunction developed hyperthyroidism 8 weeks after COVID-19 infection, confirmed by low thyroid stimulating hormone, high free thyroxine 4, and thyroid receptor antibody. She was treated and responded well to methimazole 20 mg in a few weeks. We searched the literature and found three other similar reported cases and compared those. The effects of COVID-19 infection on the immune system and the thyroid gland might explain the pathology of hyperthyroidism post-COVID-19 infection in this patient. This new-onset hyperthyroidism was found in a woman with mild symptoms and responded well to thiamazole and β-blockers.
我们报告了一例自身免疫性甲状腺疾病伴发的甲状腺功能亢进症,该病例发生在一名既往无甲状腺疾病的患者感染新冠病毒19后几周。我们的病例通过临床表现、诊断测试以及后续的患者管理进行描述,并与其他类似的报告病例进行了比较。一名28岁既往无甲状腺功能障碍病史的女性患者在感染新冠病毒19后8周出现甲状腺功能亢进症,经低促甲状腺激素、高游离甲状腺素4和甲状腺受体抗体证实。她接受了治疗,并在几周内对20毫克甲巯咪唑反应良好。我们检索了文献,发现了其他三例类似的报告病例并进行了比较。新冠病毒19感染对免疫系统和甲状腺的影响可能解释了该患者感染新冠病毒19后甲状腺功能亢进症的病理机制。这种新发的甲状腺功能亢进症在一名症状较轻的女性中被发现,对甲硫咪唑和β受体阻滞剂反应良好。