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新冠病毒感染后的甲状腺疾病:一例新发自身免疫性甲状腺疾病病例报告

Thyroid disease post-COVID-19 infection: Report of a case with new-onset autoimmune thyroid disease.

作者信息

Trinh Anh Ngoc, Nguyen Kim Han, Nguyen Dinh Van

机构信息

Internal Medicine Department, Vinmec Healthcare System, Hanoi, Vietnam.

College of Health Sciences, VinUniversity, Hanoi, Vietnam.

出版信息

Asia Pac Allergy. 2023 Mar;13(1):54-56. doi: 10.5415/apallergy.0000000000000023. Epub 2023 Apr 28.

Abstract

We present hyperthyroidism with autoimmune thyroid disease, which developed a few weeks after the COVID-19 infection in a patient with no prior thyroid disease. Our case was described with clinical presentations, diagnostic tests, and subsequent patient management and compared to other similar reported cases. A 28-year-old female patient with no prior history of thyroid dysfunction developed hyperthyroidism 8 weeks after COVID-19 infection, confirmed by low thyroid stimulating hormone, high free thyroxine 4, and thyroid receptor antibody. She was treated and responded well to methimazole 20 mg in a few weeks. We searched the literature and found three other similar reported cases and compared those. The effects of COVID-19 infection on the immune system and the thyroid gland might explain the pathology of hyperthyroidism post-COVID-19 infection in this patient. This new-onset hyperthyroidism was found in a woman with mild symptoms and responded well to thiamazole and β-blockers.

摘要

我们报告了一例自身免疫性甲状腺疾病伴发的甲状腺功能亢进症,该病例发生在一名既往无甲状腺疾病的患者感染新冠病毒19后几周。我们的病例通过临床表现、诊断测试以及后续的患者管理进行描述,并与其他类似的报告病例进行了比较。一名28岁既往无甲状腺功能障碍病史的女性患者在感染新冠病毒19后8周出现甲状腺功能亢进症,经低促甲状腺激素、高游离甲状腺素4和甲状腺受体抗体证实。她接受了治疗,并在几周内对20毫克甲巯咪唑反应良好。我们检索了文献,发现了其他三例类似的报告病例并进行了比较。新冠病毒19感染对免疫系统和甲状腺的影响可能解释了该患者感染新冠病毒19后甲状腺功能亢进症的病理机制。这种新发的甲状腺功能亢进症在一名症状较轻的女性中被发现,对甲硫咪唑和β受体阻滞剂反应良好。

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本文引用的文献

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Case Rep Endocrinol. 2020 Sep 28;2020:8891539. doi: 10.1155/2020/8891539. eCollection 2020.
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Singapore Med J. 2021 May;62(5):265. doi: 10.11622/smedj.2020106. Epub 2020 Jul 16.

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