Del Zoppo G J, Copeland B R, Waltz T A, Zyroff J, Plow E F, Harker L A
Stroke. 1986 Jul-Aug;17(4):638-43. doi: 10.1161/01.str.17.4.638.
The capacity of intracarotid infusion of urokinase to salvage neurologic function in a baboon model of acute thrombotic stroke has been studied. The model consists of reversible eccentric balloon compression (3 hours) of the right middle cerebral artery (MCA) proximal to the take-off of the lenticulostriate arteries (LSA), resulting in in situ thrombosis of perforating branches supplying the right corpus striatum. Neurologic endpoints included quantitative assessment of neurologic function (NE), estimation of cerebral infarction volume by computerized tomographic (CT) scan, and carotid angiography. In untreated acute stroke control animals (n = 6), a persistent decrease in functional score (from 100 to 36 +/- 11) at 14 days and a defined region of cerebral infarction (volume = 3.2 +/- 1.5) were detected at 10 days. Intracarotid urokinase administered to five animals (1.2 X 10(6) IU over 60 min) following the 3 hour period of MCA occlusion improved neurologic function (NE = 50, 55, 85, 100, 100) and reduced infarction size (0.3, 0.5, 0.8, 0.7, 1.1 cm3, respectively) without evidence of intracranial hemorrhage. Systemic fibrinogenolysis was produced in all five treated animals. We conclude that thrombolytic therapy given within 3 hours of experimental thrombotic occlusion may salvage neurologic function and reduce cerebral infarction volume without CT scan detectable intracranial bleeding.
已对在急性血栓性中风狒狒模型中，颈内动脉输注尿激酶挽救神经功能的能力进行了研究。该模型包括对豆纹动脉（LSA）起始部近端的右侧大脑中动脉（MCA）进行可逆性偏心球囊压迫（3小时），导致供应右侧纹状体的穿支动脉原位血栓形成。神经学终点包括神经功能的定量评估（NE）、通过计算机断层扫描（CT）估算脑梗死体积以及颈动脉血管造影。在未经治疗的急性中风对照动物（n = 6）中，在14天时功能评分持续下降（从100降至36±11），并且在10天时检测到明确的脑梗死区域（体积 = 3.2±1.5）。在MCA闭塞3小时后，对五只动物进行颈内动脉尿激酶给药（60分钟内给予1.2×10⁶ IU）改善了神经功能（NE分别为50、55、85、100、100）并减小了梗死面积（分别为0.3、0.5、0.8、0.7、1.1 cm³），且无颅内出血迹象。所有五只接受治疗的动物均出现全身纤维蛋白溶解。我们得出结论，在实验性血栓闭塞3小时内给予溶栓治疗可挽救神经功能并减小脑梗死体积，且CT扫描未检测到颅内出血。
