Jialal I, Reddi K, Omar M A, Van Dellen J R, Joubert S M
Trop Geogr Med. 1986 Jun;38(2):175-9.
Over a five year period 55 patients with pituitary tumours (35 African and 20 Indian patients) were seen at the Endocrine Unit, King Edward VIII Hospital. Of the 33 patients with secretory tumours 20 had GH-secreting tumours (acromegaly), 8 prolactinomas and 5 ACTH-producing tumours (Cushing's disease); in addition 4 of the patients with acromegaly probably had combined GH and prolactin secreting tumours. The group with non-secretory tumours comprised 13 patients with craniopharyngioma, 7 with chromophobe adenomas and 2 patients with parasellar tumours. The majority of patients with non-secretory tumours were of African descent. Hormonal deficiencies present in the patients tested, were as follows: GH deficiency 73.3%; hypocorticolism 66.7%; hypogonadism 35.9% and hypothyroidism 14%. It thus appears that the patients in the present study differ from populations studied elsewhere with respect to the relative frequency of the various secretory tumours and the prevalence of certain hormonal deficiencies.
在五年时间里，爱德华八世国王医院内分泌科诊治了55例垂体肿瘤患者（35例非洲患者和20例印度患者）。在33例分泌性肿瘤患者中，20例为生长激素分泌性肿瘤（肢端肥大症），8例为催乳素瘤，5例为促肾上腺皮质激素分泌性肿瘤（库欣病）；此外，4例肢端肥大症患者可能同时分泌生长激素和催乳素。非分泌性肿瘤组包括13例颅咽管瘤患者、7例嫌色细胞瘤患者和2例鞍旁肿瘤患者。大多数非分泌性肿瘤患者为非洲裔。检测的患者中存在的激素缺乏情况如下：生长激素缺乏73.3%；皮质醇缺乏66.7%；性腺功能减退35.9%；甲状腺功能减退14%。因此，本研究中的患者在各种分泌性肿瘤的相对频率和某些激素缺乏的患病率方面与其他地方研究的人群有所不同。
