Mental Health Research and Treatment Center, Ruhr University Bochum, Bochum, Germany.
Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Fribourg, Switzerland.
PLoS One. 2023 Jun 30;18(6):e0280402. doi: 10.1371/journal.pone.0280402. eCollection 2023.
This descriptive study examined patient characteristics, treatment characteristics, and short-term outcomes among patients with Anorexia Nervosa (AN) and Bulimia Nervosa (BN) in routine clinical care. Results for patients receiving full-time treatment were contrasted with results for patients receiving ambulatory treatment. Data of a clinical trial including 116 female patients (18-35 years) diagnosed with AN or BN were subjected to secondary analyses. Patients were voluntarily admitted to one of nine treatment facilities in Germany and Switzerland. Patients received cognitive-behavioral interventions in accordance with the national clinical practice guidelines for the treatment of EDs under routine clinical care conditions, either as full-time treatment or ambulatory treatment. Assessments were conducted after admission and three months later. Assessments included a clinician-administered diagnostic interview (DIPS), body-mass-index (BMI), ED pathology (EDE-Q), depressive symptoms (BDI-II), symptoms of anxiety (BAI), and somatic symptoms (SOMS). Findings showed that treatment intensity differed largely by setting and site, partly due to national health insurance policies. Patients with AN in full-time treatment received on average 65 psychotherapeutic sessions and patients with BN in full-time treatment received on average 38 sessions within three months. In comparison, patients with AN or BN in ambulatory treatment received 8-9 sessions within the same time. Full-time treatment was associated with substantial improvements on all measured variables for both women with AN (d = .48-.83) and BN (d = .48-.81). Despite the relatively small amount of psychotherapeutic sessions, ambulatory treatment was associated with small increases in BMI (d = .37) among women with AN and small improvements on all measured variables among women with BN (d = .27-.43). For women with AN, reduction in ED pathology were positively related to the number of psychotherapeutic sessions received. Regardless of diagnosis and treatment setting, full recovery of symptoms was rarely achieved within three months (recovery rates ranged between 0 and 4.4%). The present study shows that a considerable amount of patients with EDs improved after CBT-based ED treatment in routine clinical care within three months after admission. Intensive full-time treatment may be particularly effective in quickly improving ED-related pathology, although full remission of symptoms is typically not achieved. A small amount of ambulatory sessions may already produce considerable improvements in BN pathology and weight gain among women with AN. As patient characteristics and treatment intensity differed largely between settings, results should not be interpreted as superiority of one treatment setting over another. Furthermore, this study shows that treatment intensity is quite heterogeneous, indicating the possibility for increasing effectiveness in the treatment of EDs in routine clinical care.
这项描述性研究考察了在常规临床护理中患有神经性厌食症(AN)和神经性贪食症(BN)的患者的特征、治疗特征和短期结局。比较了接受全职治疗的患者和接受门诊治疗的患者的结果。对一项包括 116 名女性患者(18-35 岁)的临床试验数据进行了二次分析。这些患者自愿入住德国和瑞士的 9 个治疗机构之一。根据国家临床实践指南,患者在常规临床护理条件下接受认知行为干预,无论是全职治疗还是门诊治疗。在入院后和三个月后进行评估。评估包括临床医生管理的诊断访谈(DIPS)、体重指数(BMI)、饮食失调症(EDE-Q)、抑郁症状(BDI-II)、焦虑症状(BAI)和躯体症状(SOMS)。研究结果表明,治疗强度在很大程度上因环境和地点而异,部分原因是国家健康保险政策。接受全职治疗的 AN 患者平均接受了 65 次心理治疗,接受全职治疗的 BN 患者平均在三个月内接受了 38 次治疗。相比之下,接受门诊治疗的 AN 或 BN 患者在同一时间内接受了 8-9 次治疗。全职治疗与所有接受 AN(d =.48-.83)和 BN(d =.48-.81)的女性患者的所有测量变量都有显著改善。尽管接受的心理治疗次数相对较少,但门诊治疗与 AN 女性的 BMI 增加(d =.37)和 BN 女性的所有测量变量的改善有关(d =.27-.43)。对于 AN 女性,饮食失调症的改善与接受的心理治疗次数呈正相关。无论诊断和治疗环境如何,在三个月内很少有患者完全康复(康复率在 0 到 4.4%之间)。本研究表明,在接受入院后三个月内,基于认知行为的 ED 治疗后,相当多的 ED 患者在常规临床护理中得到了改善。密集的全职治疗可能特别有助于快速改善与 ED 相关的病理学,尽管症状通常不会完全缓解。少量的门诊治疗可能已经在 BN 病理学和 AN 女性的体重增加方面产生了相当大的改善。由于患者特征和治疗强度在环境之间存在很大差异,因此结果不应被解释为一种治疗环境优于另一种。此外,本研究表明,治疗强度相当多样化,这表明在常规临床护理中治疗 ED 可以提高疗效。