Ghione M
Cancer Chemother Pharmacol. 1978;1(1):24-34. doi: 10.1007/BF00253143.
Cardiotoxic effects related to treatment with some antitumor agents (chiefly anthracycline antibiotics, cylophosphamide, corticosteroids, 5-fluorouracil, and radiation therapy), their association, and contemporaneous administration of other (potentially) cardiotoxic drugs are reviewed. Experimental models, clinical findings, and diagnostic methods are briefly described. Pathogenetic factors and interactions of antitumor drugs with biomembranes, DNA, and immune reactions are discussed.
本文综述了与某些抗肿瘤药物（主要是蒽环类抗生素、环磷酰胺、皮质类固醇、5-氟尿嘧啶和放射治疗）治疗相关的心脏毒性作用、它们之间的关联以及与其他（潜在）心脏毒性药物的同时使用。简要描述了实验模型、临床发现和诊断方法。讨论了抗肿瘤药物与生物膜、DNA和免疫反应的发病机制及相互作用。
