急性淋巴细胞白血病的预后与治疗。650例患者的研究。

Prognosis and treatment of acute lymphoblastic leukemia. Study of 650 patients.

作者信息

Jacquillat C, Weil M, Auclerc M F, Chastang C, Flandrin G, Izrael V, Schaison G, Degos L, Boiron M, Bernard J

出版信息

Cancer Chemother Pharmacol. 1978;1(2):113-22. doi: 10.1007/BF00254045.

Abstract

The complete hematological remission (CHR) rate, duration of remission and survival were studied in relation to age, peripheral blast cell (PBC) count, presence or absence of tumor masses, cytological type, and treatment in 650 patients with acute lymphoblastic leukemia. Prognostic factors were considered separately and divided into prognostic classes. Age and PCB count correlated with both the rate and the duration of CHR. This correlation was still observed for more recent treatment schedules though it appears to be becoming progressively less significant. Meningeal relapses were more common in patients less than 1 year old and in those with a high PCB count. It is suggested that stratification of patients according to such factors as age, PCB count, presence or absence of tumor, and cytological type might be necessary for the design of new treatment protocols and for the evaluation of their results.

摘要

对650例急性淋巴细胞白血病患者的完全血液学缓解（CHR）率、缓解持续时间和生存期进行了研究，研究内容涉及年龄、外周原始细胞（PBC）计数、有无肿瘤肿块、细胞学类型以及治疗情况。对预后因素分别进行了考量，并划分成了预后类别。年龄和外周原始细胞计数与CHR率及缓解持续时间均相关。尽管这种相关性在最近的治疗方案中似乎逐渐变得不那么显著，但仍可观察到。脑膜复发在年龄小于1岁的患者以及外周原始细胞计数高的患者中更为常见。建议在设计新的治疗方案及其结果评估时，可能有必要根据年龄、外周原始细胞计数、有无肿瘤以及细胞学类型等因素对患者进行分层。