Vanderbilt University School of Medicine, Nashville, TN, USA.
Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
J Perinatol. 2023 Sep;43(9):1131-1138. doi: 10.1038/s41372-023-01712-6. Epub 2023 Jun 30.
Congenital Diaphragmatic Hernia (CDH) is diagnosed prenatally in ~60% of cases. Prenatal measures typically guide management and prognostication. Simple postnatal prognosticators are needed when prenatal diagnosis is lacking. We hypothesized that preoperative orogastric tube (OGT) tip position relative to the contralateral diaphragm correlates with defect severity, resource utilization, and clinical outcomes regardless of diagnostic status.
150 neonates with left-posterolateral CDH were analyzed. Impact of intrathoracic and intraabdominal preoperative tip position on clinical outcomes was compared.
Ninety-nine neonates were prenatally diagnosed. Overall, intrathoracic position significantly correlated with larger diaphragmatic defects, advanced postnatal pulmonary support requirements (HFOV, pulmonary vasodilators, and ECMO), operative complexity, longer hospitalization, and poorer survival to discharge. These observations persisted when analyzing only cases lacking prenatal diagnosis.
Preoperative OGT tip position predicts defect severity, resource utilization, and outcomes in CDH. This observation enhances postnatal prognostication and care planning for neonates without a prenatal diagnosis.
先天性膈疝(CDH)约 60%在产前诊断。产前措施通常指导管理和预后判断。当缺乏产前诊断时,需要简单的产后预后指标。我们假设术前经口胃管(OGT)尖端相对于对侧膈肌的位置与缺陷严重程度、资源利用和临床结果相关,而与诊断状态无关。
分析了 150 例左侧后外侧 CDH 新生儿。比较了胸腔内和腹腔内术前尖端位置对临床结果的影响。
99 例新生儿在产前诊断。总体而言,胸腔内位置与更大的膈肌缺陷、更高级的产后肺支持需求(高频通气、肺血管扩张剂和 ECMO)、手术复杂性、更长的住院时间和较差的出院生存率显著相关。当仅分析缺乏产前诊断的病例时,这些观察结果仍然存在。
术前 OGT 尖端位置预测 CDH 的缺陷严重程度、资源利用和结果。这一观察结果增强了对没有产前诊断的新生儿的产后预后和护理计划。