Department of Emergency, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Pritzker School of Molecular Engineering, Ben May, Department for Cancer Research, University of Chicago, Chicago, IL, USA.
Eur J Med Res. 2023 Jun 30;28(1):207. doi: 10.1186/s40001-023-01181-9.
It is critical to understand the mechanisms of human cancers in order to develop the effective anti-cancer therapeutic strategies. Recent studies indicated that primase polymerase (PRIMPOL) is strongly associated with the development of human cancers. Nevertheless, a systematic pan-cancer analysis of PRIMPOL remains to be further clarified.
Comprehensive multi-omics bioinformatics algorithms, such as TIMER2.0, GEPIA2.0 and cBioPortal, were utilized to evaluate the biological roles of PRIMPOL in pan-cancer, including the expression profiles, genomic alterations, prognostic values and immune regulation.
PRIMPOL was upregulated in glioblastoma multiforme and kidney renal clear cell carcinoma. The brain lower grade glioma patients with enhanced PRIMPOL expression displayed poor prognostic values. We also demonstrated the PRIMPOL's immunomodulating effects on pan-cancer as well as its genomic changes and methylation levels. The aberrant expression of PRIMPOL was linked to various cancer-associated pathways, including DNA damage response, DNA repair, and angiogenesis, according to single-cell sequencing and function enrichment.
This pan-cancer analysis offers a thorough review of the functional roles of PRIMPOL in human cancers, suggesting PRIMPOL as a potentially important biomarker for the progression and immunotherapy of various cancers.
了解人类癌症的机制对于开发有效的抗癌治疗策略至关重要。最近的研究表明，引发酶（PRIMPOL）与人类癌症的发展密切相关。然而，PRIMPOL 的系统泛癌症分析仍有待进一步阐明。
利用 TIMER2.0、GEPIA2.0 和 cBioPortal 等综合多组学生物信息学算法，评估 PRIMPOL 在泛癌症中的生物学作用，包括表达谱、基因组改变、预后价值和免疫调节。
PRIMPOL 在多形性成胶质细胞瘤和肾透明细胞癌中上调。表达增强的 PRIMPOL 的脑低级别神经胶质瘤患者预后不良。我们还证明了 PRIMPOL 在泛癌症中的免疫调节作用及其基因组改变和甲基化水平。单细胞测序和功能富集表明，PRIMPOL 的异常表达与包括 DNA 损伤反应、DNA 修复和血管生成在内的各种癌症相关途径有关。
这项泛癌症分析全面回顾了 PRIMPOL 在人类癌症中的功能作用，表明 PRIMPOL 可能是各种癌症进展和免疫治疗的重要生物标志物。
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