Bai Rui, Yuan Cheng
1Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
2Department of Gynecological Oncology, Zhongnan Hospital, Wuhan University, Wuhan, China.
Aging Dis. 2022 Jul 11;13(4):1267-1277. doi: 10.14336/AD.2021.1207.
Cancer has always been a huge problem in the field of human health, and its early diagnosis and treatment are the key to solving this problem. Cancer testis antigens (CTAs) are a family of multifunctional proteins that are specifically expressed in male spermatozoa and tumor cells but not in healthy somatic cells. Studies have found that CTAs are involved in the occurrence and development of tumors, and some CTAs trigger immunogenicity, which suggests a possibility of tumor immunotherapy. The differential expression and function of CTAs in normal tissues and tumor cells can promote the screening of tumor markers and the development of new immunotherapies. This article introduces the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC-1), a new member of the CTA family, in different types of tumors and its role in immunotherapy.
癌症一直是人类健康领域的一个重大问题，其早期诊断和治疗是解决这一问题的关键。癌睾丸抗原（CTA）是一类多功能蛋白质，在男性精子和肿瘤细胞中特异性表达，但在健康体细胞中不表达。研究发现，CTA参与肿瘤的发生和发展，一些CTA会引发免疫原性，这提示了肿瘤免疫治疗的可能性。CTA在正常组织和肿瘤细胞中的差异表达及功能，可促进肿瘤标志物的筛选和新免疫疗法的开发。本文介绍了CTA家族新成员九州肺癌抗原-1（KK-LC-1）在不同类型肿瘤中的表达及其在免疫治疗中的作用。
