Wang Huizeng, Liu Bingchun, Chen Hong, Xu Peixin, Xue Huiting, Yuan Jianlong
Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
Stem Cell Research Center, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, China.
Genes Environ. 2023 Jul 1;45(1):21. doi: 10.1186/s41021-023-00278-1.
Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene expression, and thereby induced cancer. It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development.
苯并(a)芘（BaP）是多环芳烃（PAHs）中最早且最重要的致癌物，已在食品、烟草烟雾和汽车尾气等中被发现。接触BaP会直接诱导DNA损伤，或引发与氧化应激相关的损伤，从而导致人体呼吸系统、消化系统、生殖系统等发生细胞凋亡和癌变。此外，BaP通过甲基化引发全基因组表观遗传改变，这可能会导致基因表达调控紊乱，进而诱发癌症。已证实BaP会降低全基因组DNA甲基化水平，并通过启动子区域的低甲基化激活原癌基因，但通过启动子高甲基化使肿瘤抑制基因沉默，从而导致癌症的发生和发展。在此，我们总结了BaP暴露下DNA甲基化的变化，并揭示了DNA甲基化在癌症发展中发挥作用。
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