Department of General Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Department of Emergency Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nanlishi Road, Xicheng District, Beijing, 100045, China.
Pediatr Surg Int. 2023 Jul 1;39(1):223. doi: 10.1007/s00383-023-05497-9.
To investigate the relationship of IgE-mediated allergy and complicated appendicitis (CA) and overall prognosis.
We retrospectively analyzed a consecutive series of patients with acute appendicitis (AA) who received appendectomy at Beijing Children's Hospital between July 1, 2018 and June 30, 2020. Patients were classified into two groups, with or without IgE-mediated allergies. Logistic regression adjusting for age, duration of symptoms, WBC count, neutrophil count, C-reactive protein (CRP), Appendicolith and presence of allergy was used to evaluate the association between CA and IgE-mediated allergy.
In total, 1156 patients were included. 162 (14.0%) of the patients had IgE-mediated allergy while 994 (86.0%) did not. Children with allergies had a decreased chance of developing CA after adjustment for age, duration of symptoms, WBC count, Neutrophil count, CRP, and appendicolith present rate (adjusted OR = 0.582, 0.364-0.929, P = 0.023). There were no significant differences in operative time, length of hospital stay (LOS), readmission, or adhesive intestinal obstruction rate between allergy and non-allergy patients.
IgE-mediated allergy is related to a reduction risk of CA in the pediatric population and may not affect the prognosis of patients received appendectomy.
探讨 IgE 介导的过敏与复杂阑尾炎（CA）及总体预后的关系。
我们回顾性分析了 2018 年 7 月 1 日至 2020 年 6 月 30 日期间在北京儿童医院接受阑尾切除术的连续急性阑尾炎（AA）患者的系列病例。患者分为两组，有无 IgE 介导的过敏。采用调整年龄、症状持续时间、白细胞计数、中性粒细胞计数、C 反应蛋白（CRP）、阑尾结石和过敏存在的 logistic 回归来评估 CA 与 IgE 介导的过敏之间的关系。
共纳入 1156 例患者。162 例（14.0%）患者存在 IgE 介导的过敏，994 例（86.0%）患者无 IgE 介导的过敏。在调整年龄、症状持续时间、白细胞计数、中性粒细胞计数、CRP 和阑尾结石发生率后，过敏儿童发生 CA 的几率降低（调整后的 OR=0.582，0.364-0.929，P=0.023）。过敏和非过敏患者的手术时间、住院时间（LOS）、再入院率或粘连性肠梗阻发生率无显著差异。
IgE 介导的过敏与儿科人群中 CA 风险降低相关，且可能不影响接受阑尾切除术患者的预后。
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