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Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics.
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The essential role of the transporter ABCG2 in the pathophysiology of erythropoietic protoporphyria.
Sci Adv. 2019 Sep 18;5(9):eaaw6127. doi: 10.1126/sciadv.aaw6127. eCollection 2019 Sep.
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Erythropoietic protoporphyrias: updates and advances.
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Inactivation of protoporphyrin IX in erythrocytes in patients with erythropoietic protoporphyria: A new treatment modality.
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Repurposing of glycine transport inhibitors for the treatment of erythropoietic protoporphyria.
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Erythropoietic Protoporphyria and X-Linked Protoporphyria: pathophysiology, genetics, clinical manifestations, and management.
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Inhibition of ABCG2 prevents phototoxicity in a mouse model of erythropoietic protoporphyria.
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Heme (dys)homeostasis and liver disease.
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Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management.
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Photochemical and biological dual-effects enhance the inhibition of photosensitizers for tumour growth.
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Iron metabolism: backfire of cancer cell stemness and therapeutic modalities.
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Roles of the ABCG2 Transporter in Protoporphyrin IX Distribution and Toxicity.
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2
Results from a first-in-human study of dersimelagon, an investigational oral selective MC1R agonist.
Eur J Clin Pharmacol. 2023 Jun;79(6):801-813. doi: 10.1007/s00228-023-03476-6. Epub 2023 Apr 15.
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Dersimelagon in Erythropoietic Protoporphyrias.
N Engl J Med. 2023 Apr 13;388(15):1376-1385. doi: 10.1056/NEJMoa2208754.
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How I treat erythropoietic protoporphyria and X-linked protoporphyria.
Blood. 2023 Jun 15;141(24):2921-2931. doi: 10.1182/blood.2022018688.
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The Oral Bioavailability and Effect of Various Gastric Conditions on the Pharmacokinetics of Dersimelagon in Healthy Adult Volunteers.
Clin Pharmacol Drug Dev. 2023 May;12(5):493-501. doi: 10.1002/cpdd.1235. Epub 2023 Feb 25.
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Evidence-based consensus guidelines for the diagnosis and management of erythropoietic protoporphyria and X-linked protoporphyria.
J Am Acad Dermatol. 2023 Dec;89(6):1227-1237. doi: 10.1016/j.jaad.2022.08.036. Epub 2022 Aug 27.
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Melanogenic effect of dersimelagon (MT-7117), a novel oral melanocortin 1 receptor agonist.
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Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria.
Sci Rep. 2022 Apr 12;12(1):6100. doi: 10.1038/s41598-022-10089-z.

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