Department of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, 25-1 Shichibancho, Wakayama 640-8156, Japan.
Department of Pharmacotherapeutics, School of Pharmaceutical Science, Wakayama Medical University, 25-1 Shichibancho, Wakayama 640-8156, Japan.
Peptides. 2023 Sep;167:171050. doi: 10.1016/j.peptides.2023.171050. Epub 2023 Jun 29.
Desacyl-ghrelin is a form of ghrelin which lacks acyl-modification of the third serine residue of ghrelin. Originally, desacyl-ghrelin was considered to be just an inactive form of ghrelin. More recently, however, it has been suggested to have various biological activities, including control of food intake, growth hormone, glucose metabolism, and gastric movement, and is involved in cell survival. In this review, we summarize the current knowledge of the biological actions of desacyl-ghrelin and the proposed mechanisms by which it exerts the effects.
去酰基-生长激素释放肽是一种缺乏生长激素第三丝氨酸残基酰化修饰的形式。最初，去酰基-生长激素释放肽被认为只是生长激素的一种无活性形式。然而，最近有研究表明，它具有多种生物活性，包括控制食物摄入、生长激素、葡萄糖代谢和胃运动，并参与细胞存活。在这篇综述中，我们总结了去酰基-生长激素释放肽的生物学作用及其作用机制的最新知识。
