Department of Spine Surgery and Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Br J Radiol. 2023 Oct;96(1150):20230117. doi: 10.1259/bjr.20230117. Epub 2023 Jul 3.
Breast cancer is by far the most common malignancy in females. And bone is the most common site of distant metastasis in breast cancer, accounting for about 65 to 75% of all metastatic breast cancer patients.Bone metastasis is an important factor affecting the prognosis of breast cancer. When patients have early-stage breast cancer without metastasis, their 5-year survival rate is as high as 90%, and once metastasis occurs, their 5-year survival rate will drop to 10%. Bone radionuclide imaging (ECT), X-ray, CT scan, MRI and other imaging tests to diagnose breast cancer bone metastasis are commonly used in clinical, It is currently believed that breast cancer bone metastasis is a multistep process: first, breast cancer cells need to acquire invasive and metastatic properties; breast cancer cells enter the blood circulation and migrate from blood breast cancer cells enter the blood circulation and migrate from blood vessels to bone tissue in a targeted manner; breast cancer cells adhere and remain in bone tissue and colonise it; and finally, it leads to bone destruction. Several key molecules are involved in breast cancer bone metastasis, and serum biomarkers are generally able to detect pathological changes earlier Several key molecules are involved in breast cancer bone metastasis, and serum biomarkers are generally able to detect pathological changes earlier than imaging. This review describes the progress of serum biomarkers for breast cancer bone metastasis.
乳腺癌是女性最常见的恶性肿瘤。骨骼是乳腺癌远处转移最常见的部位，约占所有转移性乳腺癌患者的 65%至 75%。骨转移是影响乳腺癌预后的重要因素。当患者患有无转移的早期乳腺癌时，其 5 年生存率高达 90%，一旦发生转移，其 5 年生存率将下降至 10%。核素骨显像（ECT）、X 线、CT 扫描、MRI 等影像学检查常用于临床诊断乳腺癌骨转移，目前认为乳腺癌骨转移是一个多步骤的过程：首先，乳腺癌细胞需要获得侵袭性和转移性特性；乳腺癌细胞进入血液循环并从血管中定向迁移到骨组织；乳腺癌细胞黏附和定植于骨组织并殖民化；最后，导致骨破坏。乳腺癌骨转移涉及几个关键分子，而血清标志物通常能够比影像学更早地检测到病理变化。本文综述了乳腺癌骨转移的血清标志物的研究进展。
