Department of Emergency Medicine, Kings County Hospital, SUNY Downstate Medical Center, Kings County Hospital Center, Room CG65, 451 Clarkson Avenue, Brooklyn, NY 11203, USA.
Department of Emergency Medicine, Kings County Hospital, SUNY Downstate Medical Center, Kings County Hospital Center, Room CG65, 451 Clarkson Avenue, Brooklyn, NY 11203, USA.
Immunol Allergy Clin North Am. 2023 Aug;43(3):593-612. doi: 10.1016/j.iac.2022.10.001.
The spondyloarthritides are a diverse group of distinct yet interrelated disease processes with overlapping clinical features. They are ankylosing spondylitis, reactive arthritis, inflammatory bowel disease-associated arthritis, and psoriatic arthritis. Genetically, these disease processes have been linked by the presence of HLA-B27. They manifest with axial and peripheral symptoms, such as inflammatory back pain, enthesitis, oligoarthritis, and dactylitis. The onset of symptoms can begin before the age of 45; however, because of the wide range of signs and symptoms, diagnosis can be delayed, leading to unchecked inflammation, structural damage, and later, restriction in physical mobility.
脊柱关节炎是一组具有不同特征但相互关联的疾病过程，具有重叠的临床特征。它们包括强直性脊柱炎、反应性关节炎、炎症性肠病相关关节炎和银屑病关节炎。在遗传上，这些疾病过程与 HLA-B27 的存在有关。它们表现为轴性和外周症状，如炎症性背痛、肌腱附着点炎、少关节炎和指（趾）炎。症状的发作可在 45 岁之前开始；然而，由于症状的广泛表现，诊断可能会被延迟，导致炎症不受控制、结构损伤，以及随后的身体活动受限。
